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Modalert Uses- Understanding Its Cognitive And Wakefulness Enhancing Property

Modalert Uses- Understanding Its Cognitive And Wakefulness Enhancing Property

Last updated on 13 May, 2024

Modalert is a wake-promoting compound that is approved for the treatment of excessive daytime sleepiness associated with Narcolepsy, Obstructive Sleep Apnea, and Shift Work Disorder.

The off-label uses of Modalert for enhancing mood, cognitive ability, and chronic fatigue disorder are supported by several clinical studies and are considered safe with no severe health risks.

Modalert has gained significant attention for its numerous uses, especially because of its off-label uses for the enhancement of cognitive functions.

In this blog, we will cover the various Modalert prescription uses along with their benefits, dosage, and reviews, and we will compare the smart drug with other sleep disorder medicines.

What Is Modalert: The Basics

Modalert is the brand name for generic Modafinil, a wakefulness-promoting agent that is used to treat excessive daytime sleepiness caused by several sleep disorders. 

Sun Pharmaceuticals manufactures Waklert, and it functions by influencing specific neurotransmitters in the brain that control wakefulness and sleep.

Who Prescribes Modalert ?

Modalert is prescribed by an endocrinologist, neurologist, internist, sleep specialist, or pulmonologist to treat daytime sleepiness, mental health disorders such as ADHD, depression, and respiratory troubles [1].

What Are The Sleep Disorders Treated With Modalert?

The use of Modafinil as a wakefulness enhancer is approved by the FDA for treating excessive daytime sleepiness associated with the conditions mentioned below:


Narcolepsy is a long-term neurological condition that affects the brain’s ability to control the sleep-wake cycle, greatly affecting daily activities. The FDA approved Modalert to treat this condition in 1998.

Obstructive Sleep Apnea:

The most prevalent sleep disorder is obstructive sleep apnea, or OSA, which results from the collapse of a person's upper airway while they are asleep.

This disorder occurs when the muscles that support the soft tissues in the throat (tongue and soft palate) relax. This, in turn, causes the airway to narrow or even close, cutting off your breathing momentarily [2].

Shift Work Disorder:

Shift Work Disorder is a circadian rhythm sleep disorder that is characterized by excessive sleepiness and primarily affects people who work night shifts, rotating shifts, and early morning shifts for their jobs [3]. Such people often suffer from sleepiness during working hours, thus largely affecting their productivity. Purchasing Modafinil 200 mg can help such workers stay active during the night time by elevating the secretion of hormones such as orexin and histamine.

What Are The Benefits Of Modalert?

Five important benefits of Modalert are listed below:

  • Enhanced focus and concentration.

  • Increased productivity.

  • Improves Wakefulness and alertness.

  • Mood Enhancement.

  • Increased motivation [4].

Dosage And Administration: How To Take Modalert



The  standard recommended dosage of Modalert for all its prescription uses, including narcolepsy, obstructive sleep apnea, and shift work disorder, is 200 mg.

It should be taken in the morning for narcolepsy and obstructive sleep apnea and about 60 minutes before work by night shift workers.

Administration Guidelines

Follow the five administration guidelines in order to avoid the Modalert side effects:

  • Swallow the whole medicine with a glass of water.

  • Do not chew or crush it.

  • Take it with or without meals, as the doctor prescribes.

  • Take the tablet at the same time of the day for better effectiveness,

  • The best time to take this medicine is in the morning because taking it just before bedtime. Taking the dose in the evening can impact your normal sleep schedule, causing insomnia.

Modalert Vs. Other Sleep Disorder Medicines

Let's compare Modalert with other sleep disorder medicines so that we can become aware of the most effective nootropic that one should go for.

Modalert vs. Waklert

Both Modalert and Waklert promote wakefulness, but they are different in various ways.




Drug type

Central nervous system stimulant.

Central nervous system stimulant.

Active compound




The Standard Modalert dosage is 200 mg.

The Standard Waklert dosage is 150 mg.


Per pill is $1.4

Per pill is $1.9

Route of administration

Orally by mouth

Orally by mouth

Though both Modalert and Waklert are wakefulness-promoting agents, they share many similarities with each other, such as the onset of action, pregnancy category, effect hours, time of dosage, etc.

The main difference between the two lies in their prices, as Modalert is more affordable compared to Waklert.

Modalert vs. Adderall

Modafinil vs. Adderall - A comparison looked for by people wishing to get better brain function and improve daytime sleepiness.




Generic name



FDA approval

Yes, 1998

Yes, 2002

Class of drug

CNS stimulant

CNS stimulant


Schedule IV

Schedule II

Risk of withdrawal




$1.2 per pill

$3 to $15 [5]

Addiction liability

Very low to low


The comparison between Modalert and Adderall suggests that Modalert is a safer and more affordable option than Adderall.

Modalert Research And Studies

There are several clinical studies that support the medical uses of Modalert. Some of the most prominent pieces of research on Modalert are listed below:

Modalert for Cognitive Enhancement

A study by Battleday and Brem in 2015 indicated that Modalert could enhance cognitive performance in domains like memory, executive functions, attention, alertness, and response accuracy [6].

Modalert for Wakefulness

A study, namely Modafinil in the treatment of excessive sleepiness, published in 2008 concluded that multiple clinical studies indicate that Modalert (Modafinil) is a well-tolerated and effective treatment option in the clinical management of excessive sleepiness in patients with Narcolepsy, Obstructive Sleep Apnea, and Shift Work Disorder.

Long-term studies indicate no adverse events and a low likelihood of building tolerance for scheduled sleep. Further, Abuse liability reviews show limited potential for abuse [7].

Modalert Reviews: User Experience

Modalert has an average rating of 7.2 out of 10 on the website About 63% of the users reported a positive experience after taking the Nootropic [8].




Modalert Oral Uses: Our Final Verdict

Along with its prescription uses in recent times, Modalert has gained a lot of attention for its off-label uses. This medicine is well tolerated, with minimal side effects that usually subside over the course of time.

Various studies have also indicated the use of Modalert in various cognitive domains, making it a powerful medication.


No, the use of Modalert is not recommended for children.

Yes, Modalert is sometimes prescribed by doctors to people with jet lag.

The long-term use of Modalert can cause psychological and physical dependence on the drug.

Yes, Modalert is used off-label to treat chronic fatigue syndrome.

If you miss a dose of Modalert, then skip the missed dose and return to your normal dosing schedule.

The best time to take Modalert is generally in the morning.

Yes, Modafinil does suppress appetite.

It takes around 30 to 60 minutes for Modafinil to kick in.


  1. Get Modafinil Prescription Now: Tips to Succeed, southernmarylandchron
  2. Obstructive Sleep Apnea, Healthline

  3. Shift Work Disorder, Sleepfoundation

  4. Modafinil benefits|top 6, thebigbrainbrand

  5. Adderall Street Value & Price | How Much Does Adderall Cost?arkbh

  6. Modeafinil-Induced Changes in Functional Connectivity in the Cortex and Cerebellum of Healthy Elderly Subjects, frontiersin
  7. Modafinil in the treatment of excessive sleepiness, NCBI

  8. Modafinil user reviews and ratings,


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.