Nootropics Armodafinil vs Modafinil | Modafinil vs Armodafinil

Armodafinil Vs Modafinil

Last updated on June 14th, 2022

Let us try to find answers to the long-term Nootropic comparison- Armodafinil vs. Modafinil. We all have dreams and aspirations. However, reaching the goal is not an easy task. It calls for a lot of hard work and dedication. There will be several nights when the person will not be able to sleep well. However, this can at times make the person feel very tired and sleepy. Therefore, in such a condition, it can affect the productivity of a person. Moreover, at this stage can we have a setback? I think none of us would like to compromise on our dreams just because we were not able to get a good night’s sleep. Therefore the best thing to do in such a case is to use Nootropics.

Now I agree there are different kinds of smart drugs on the market. However, choosing the right smart drugs can be a little difficult. Moreover, among all the smart drugs that are found on the market, the most talked about are Armodafinil and Modafinil. But how do we choose the right among the two? Moreover, if you too are willing to get smart drugs but are not able to figure out the right one for you. Thus, this blog is just for you. This article on Armodafinil vs Modafinil will focus on both the Armodafinil and Modafinil Nootropics. Therefore, let us have better insight on the use of Nootropics with a detailed comparison of Armodafinil vs Modafinil to help you choose better.

Armodafinil vs Modafinil: Time to choose the Right Nootropic

In this debate on Armodafinil vs Modafinil, both the Nootropics are seen to possess similarities and differences. However, both belonging to the same class of drug shows a similar mechanism of action. Here is a basic comparison of both the Nootropics to help you get a better understanding of the product information, uses, and benefits of widely popular Nootropics.


Modafinil 200mg:

Modafinil is available under the brand name Provigil, Modvigil, and Modalert. In addition, this medication is very effective in reducing the sign of excessive daytime sleepiness. However, people suffer from sleep disorders such as shift work sleep disorder, narcolepsy, and obstructive sleep apnea. Moreover, for off-label use, users get Modafinil for its effectiveness in enhancing cognition in people. Thus, the emergence of online pharmacies now allows users to purchase Modafinil at the best price. This smart drug is the primary metabolite of adrafinil. It was in the year 1998 that Modafinil got approval from the food and drug administration for treating narcolepsy. Modafinil along with its brand names Provigil and Modalert is used to treat sleep disorders. However, it can occur from shift work sleep disorder and obstructive sleep apnea.


Armodafinil 150mg:

Armodafinil is an enantiopure compound of Modafinil. Moreover, this Nootropic contains the (R)-(-) enantiomer of Modafinil. It is produced by Cephalon Pharma Company. The use of Armodafinil was approved by the food and drug administration in the year June 2007. Since Armodafinil comes from Modafinil, therefore it is more potent when you compare it to its generic version. However, the Armodafinil online price in the USA is also comparatively lower than Modafinil. This makes it a much more affordable choice.

Modafinil vs Armodafinil- basic comparison between the two Nootropics

Armodafinil contains different amounts of Armodafinil in the formulation. Moreover, the amount of Armodafinil may vary from 50mg; to 150mg, 200mg, and 250mg. Along with the key compound, there are many other inactive compounds such as Lactose monohydrate, Croscarmellose sodium. In addition, it also has Magnesium stearate, Povidone, Pregelatinized Starch, and Microcrystalline cellulose. Modafinil contains either 100mg or 200mg of Modafinil. The inactive compounds are- povidone, Microcrystalline cellulose, and Croscarmellose sodium. In addition, it also contains Pregelatinized starch, Microcrystalline cellulose, and Lactose monohydrate. 
The dose that experts usually recommend is Armodafinil 150 mg. The Modafinil dose that is advisable for your usage is 200mg.
The working mechanism of the Nootropics
Firstly, the pharmacological properties of Armodafinil are close to that of Modafinil. However, the wake-promoting action of Armodafinil is similar to that of sympathomimetic agents. Thus, it means they mimic the endogenous agents and work on the sympathetic nerve of a person such as the amphetamine and methylphenidate. In addition, it is an indirect dopamine receptor agonist that binds to the dopamine transporter. Therefore, it further inhibits the dopamine reuptake.

Secondly, the onset of action is 30 minutes.


Firstly, the Modafinil acts as an atypical weak and selective dopamine reuptake inhibitor. Therefore, it, directly and indirectly, activates the release of orexin neuropeptides. 

Secondly, it also releases histamine from the lateral hypothalamus region of the brain.  Moreover, the tuberomammillary nucleus is also responsible for contributing to arousal.

In other words, the intake of Modafinil is also responsible for the release of hormones such as dopamine and histamine. Therefore, this plays a key role in promoting wakefulness in the person.

Thirdly, the onset of action of Modafinil is 30 minutes.

Peak of action
Armodafinil reaches peak effects in little time when compared to Modafinil. In other words, for Armodafinil to reach the peak it takes about 2 hours. Also, the declining process of smart drugs is very slow. Modafinil, however, takes about 4 hours to reach its peak. Moreover, the effect of smart drugs usually remains for about 2 to 3 hours before it starts to diminish gradually.
Duration of effect
The action of Armodafinil lasts for about 18 hours after the intake of this medicine. However, Its effect is also stronger than other smart drugs. The Modafinil acts for about 16 hours in the person.
Side effects of Nootropics
The side effects that are seen in people taking the Armodafinil dose are mild when compared to that of Modafinil. However, the common side effects that can be seen in people taking this smart drug are- headaches, stomach upset, and excessive sweating. In addition, suffering from agitation, and mood swings is common.  Not all people taking the nootropic dose have to suffer from side effects. However, they might show side effects- palpitation in heart patients, depression, blurry vision in case of overdosage. In addition, one can also experience stomach issues, and trouble sleeping.

Conditions treated by Armodafinil and Modafinil

Armodafinil and Modafinil are both prescription drugs that are approved by the FDA. It is widely popular for several off-label benefits. The onset of action of both the Nootropic begins within thirty minutes of intake. However, its eugeroic property makes it very effective for managing excessive daytime sleepiness in people. Thus, some of the prescription and off-label use of both the Nootropics are listed down below-

Condition Armodafinil 150mg Modafinil 200mg
Shift work sleep disorder Yes Yes
Narcolepsy Yes Yes
Obstructive sleep apnea Yes Yes
Mental health issues (depression, ADHD) Off-label Off-label
Multiple sclerosis-related fatigues Off-label Off-label
Cognition enhancement Off-label Off-label
Cancer-related fatigue Off-label Off-label

Which among Armodafinil and Modafinil is better for Obstructive sleep apnea?

Obstructive sleep apnea is a sleep disorder that can stop a person from getting enough sleep at night. Patients with obstructive sleep apnea can also lose their active energy due to a lack of proper sleep. Smart drugs like Modafinil or Armodafinil cannot cure these conditions. These smart drugs can help patients with obstructive sleep apnea to stay active during working hours. Both the Nootropics are seen to be equally effective and potential in managing Obstructive sleep apnea.

Armodafinil vs Modafinil: Which one do you choose to treat shift work sleep disorder?

Shift work sleep disorder is a sleeping disorder in people who have to work different shifts. The normal sleep cycle makes it common to feel tired, low, and sleepy in the nighttime. This can affect the productivity of people. Therefore, people can take Modafinil or Armodafinil dosage just before starting their work shift. Moreover, during the administration, follow Modafinil and Armodafinil warnings to ensure the chances of side effects are low. It should be taken about 30 minutes before work. In the comparison study of Armodafinil vs. Modafinil, both show similar efficacy in treating obstructive sleep apnea. However, a lower dose of Armodafinil is required in comparison to Modafinil to show the same effect.

Armodafinil vs Modafinil- Comparison of their price and affordability

The cost of both Armodafinil and Modafinil differs depending on the pharmacy. Moreover, the package and strength of Nootropics are also important.  However, both the medications are available in different doses. In addition, they differ in their generic and brand versions. Also, insurance plans cover the cost of both the Nootropics. Therefore, one can further use Armodafinil and Modafinil coupons for further savings.

Modafinil Armodafinil
Coverage by Insurance Yes Yes
Coverage by Medicare Yes Yes
Standard dose Modafinil 200mg Armodafinil 150mg
Price at Healthmatter $1.3 $1.6
Additional discounts at Healthmatter Extra free pills on first order with additional offers on festive seasons Extra free pills on first order with additional offers on festive seasons
Shipping fee Free shipping Free shipping
Coupon Available Available

Modafinil vs Armodafinil- Side effects

Common side effects of Modafinil and Armodafinil are mild with no severe or life-threatening symptoms. Similarly, reports indicate that Modafinil has a higher chance of causing side effects than Armodafinil. Moreover, the occurrence of side effects from both the Nootropics is not common. However, it may occur under the circumstances such as overdosing. In addition, improper administration of drugs, and drug interactions can also cause side effects.

Armodafinil vs Modafinil- Common side effects

Adverse effects Armodafinil frequency Modafinil frequency
Insomnia 5% 5%
Headache 17% 34%
Back pain No 7%
Nausea 7% 11%
Dry mouth 4% 4%
Indigestion 2% 5%
Decreased appetite 1% 4%
Nervousness 1% 7%
Dizziness 5% 5%

However, this is not a complete list of all the possible side effects of Armodafinil and Modafinil. Therefore, depending on the cause and the dose taken, the severity of the condition may vary. In addition, if the condition persists or gets worsens with time, it is advisable to consult a doctor. However, it is important to note that these are mild signs. Therefore, they do not require immediate medical help.

Armodafinil and Modafinil warnings and precautions

Modafinil and Armodafinil are safe for use and are commonly recommended to all people. However, under certain conditions, one should refrain from the use of Nootropics as it can enhance the chances of side effects. In addition, taking the Nootropic in such conditions can increase the chances of side effects. Thus, it is important to follow these warnings and precautions. Moreover, the Nootropic precaution and warnings that should be taken into consideration while administering the drug are-

Factors Armodafinil  and Modafinil warnings


Firstly, the use of Armodafinil 150mg and Modafinil 200mg is not recommended for people above the age of 65 years.  Secondly, people below 17 years can take the dose after consulting a doctor. However, this is because such people have lower metabolic abilities.

Pregnancy and lactating women

Both the Nootropics are Category C drugs. Therefore it should not be taken during pregnancy and breastfeeding. Thus, in such a situation consult a doctor.

History of abuse

People with a history of chemical abuse should always take Nootropics with a valid medical prescription. In other words, such people are prone to experience side effects.

Health disorder

Users with kidney, liver, and heart issues should not take Modafinil and Armodafinil doses without a prescription. However, such people can experience severe side effects.

Drug interaction

The intake of other medications and supplements with Modafinil and Armodafinil can cause drug interactions. Therefore, it can lower the efficacy and potency of the medication. Moreover, this makes the medication take longer to work and shows an effective result in the user. In other words, do not take other medicine with Nootropic for a few hours before or after dosage.

Alcohol interaction

The intake of Armodafinil and Modafinil with alcohol can make the person tolerant. In addition, it can develop signs of nausea, dizziness, and drowsiness. Moreover, it can also cause lower bp.

Our Final thoughts

Firstly, we believe both the Nootropics are very effective and potent in helping achieve health benefits. They have both excelled in their achieving both prescription and off-label benefits. Secondly, the use of these Nootropics similar onset of action. Thirdly, the time of action remains closely the same. Thus, making it hard for one to choose the right one. Therefore, this blog focuses on helping you come to a decision. Thus, people looking for a Nootropic can choose Armodafinil 150mg. However, the price of Modafinil is lower. Therefore, depending on your need you can choose the right Nootropic for you.

– Disclaimer –

The team of aims to give proper and correct information to the readers. Firstly, it is for information purposes only. Secondly, the content of this blog should not be taken as professional medical advice, diagnosis, or treatment. Moreover, the information present is from several papers and journals. Thus due credit is given to all websites. Therefore, before taking any medicine it is best to consult a doctor. 

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