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14 Oct, 2022 
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The comparison between both substances found that nootropics are similar in effectiveness. However, Armodadfinil has a longer-lasting effect than Modafinil, whereas Modafinil is cheaper than Armodafinil.
Are you wondering What to choose? Is it difficult for you to choose between Armodafinil and Modafinil?
This Comprehensive Guide has laid out all the comparisons between the Nootropics and will make it easier for you to choose the best option according to your requirements.
Armodafinil And Modafinil: An Introduction To Both Nootropics
Modafinil is a medication that treats excessive sleepiness associated with Narcolepsy, Obstructive Sleep Apnea, and Shift Work Disorders. It was founded in 1974 by Michel Jouvet and L. Lafon Laboratories in France. The use of this Nootropic was approved by the FDA in 1998. It is sold under the brand name "Modalert."
The use of Modafinil is widely increasing with time for its off-label benefits. Some of the benefits include depression, ADHD, fatigue, cognitive enhancement, etc.
Armodafinil is another wakefulness-promoting agent that is the R - enantiomer of Modafinil and helps treat Sleep disorders like Narcolepsy, Obstructive Sleep Apnea, and other Shift Work Disorders. The use of Armodafinil was approved in the year 2007 by the FDA.
Armodafinil does not completely cure Sleep Disorders but helps reduce their symptoms. The drug is sold under the brand name "Waklert"
Similarities Between Armodafinil And Modafinil
The medical Uses for both substances are similar. Besides these, there are a few other similarities between Modafinil and Armodafinil. Some of these are listed below.
Controlled Substances
They are both considered controlled substances and are available only with a prescription [3].
Mechanism Of Action
Armodafinil and Modafinil function in the brain's hypothalamus region. They both enhance wakefulness by interacting with the CNS and increasing the level of dopamine and histamine in the brain.
Performance
The onset of action of both Modafinil and Armodafinil is 30 minutes.
Interaction with Food
The intake of food with Armodafinil and Modafinil can delay the onset of action of the Nootropics by 1 to 2 hours. However, it does not affect the bioavailability of the drug.
Pregnancy Category
Both modafinil and Armodafinil are not approved for use in pregnant women. They are both category C medications, with animal studies indicating potential health risks in infants.
What Are The Major Differences Between Armodafinil And Modafinil?
There is no doubt that Armodafinil and Modafinil share a lot of similarities. However, there are certain factors that keep them apart. Let's discuss these factors.
Standard Recommended Dosage
The standard recommended dosage for Modafinil is 200 mg/day, and that for Armodafinil is 150 mg/day. Both are oral medications that come in tablet form.
Half-life
The half-life of a drug determines how long it persists in your system and how long it takes your body to eliminate it. Armodafinil has a longer half-life as compared to Modafinil.
This is one of the reasons why Armodafinil is considered stronger than Modafinil and is known better for Wakefulness.
Chemical Structure
This is one of the significant differences between Armodafinil and Modafinil. Armodafinil is considered a newer drug and is the R-enantiomer of Modafinil.
Potency
Armodafinil generally has longer-lasting effects than Modafinil. It has higher peak plasma concentrations than modafinil, resulting in better wakefulness [2].
What Are The Medical Benefits Associated With Armodafinil And Modafinil?
Modafinil and Armodafinil, both nootropics, have similar on-label and off-label Medical benefits. Here's a summary of some of the potential and common prescription benefits of nootropics.
|
Condition |
Armodafinil 150mg |
Modafinil 200mg |
|---|---|---|
|
Shift Work Sleep Disorder |
yes |
yes |
|
Narcolepsy |
yes |
yes |
|
Obstructive Sleep Apnea |
yes |
yes |
|
Multiple Health Issues |
Off-label |
Off-label |
|
Multiple Sclerosis Related Fatigue |
Off-label |
Off-label |
|
Cognition Enhancement |
Off-label |
Off-label |
|
Cancer-related Fatigue |
Off-label |
Off-label |
Cost Efficiency Of Armodafinil And Modafinil
The cost of Armodafinil and Modafinil generally depends on different pharmacies as well as the package of your product. If you order medicines in bulk, you can get additional discounts.
However, it might also depend on your insurance policies. You can avail yourself of discounts through your Insurance Discount Cards. You can also claim insurance if you have a valid medical prescription.
|
Factors |
Modafinil |
Armodafinil |
|
|---|---|---|---|
|
Coverage by Insurance |
Yes |
Yes |
|
|
Coverage by Medicare |
Yes |
Yes |
|
|
Standard dose |
Modafinil 200mg |
Armodafinil 150mg |
|
|
Price at Healthmatter |
|||
|
Additional discounts at Healthmatter |
|
||
|
Shipping fee |
Free shipping on Modafinil and Armodafinil is available at Healthmatter. It may vary depending on the pharmacy. |
||
|
Coupon |
Available |
Available |
|
Which Is More Effective- Armodafinil Or Modafinil?
Although the effects of both nootropics are similar and effective for treating excessive sleepiness.
However, it must be stated that Armodafinil has longer-lasting effects than Modafinil.
The plasma concentrations of Armodafinil are high in the body. The higher the plasma concentrations, the better the wakefulness [1].
What Are The Potential Side Effects Of Both Nootropics?
The side effects of Armodafinil are generally lower compared to Modafinil. Both nootropic side effects are mild and have a low probability of causing life-threatening issues.
|
Adverse Effects |
Armodafinil Side Effects Frequency |
Modafinil Side Effects Frequency |
|---|---|---|
|
Insomnia |
5% |
5% |
|
Headache |
17% |
34% |
|
Backpain |
nil |
7% |
|
Dry Mouth |
4% |
4% |
|
Indigestion |
2% |
5% |
|
Decreased Appetite |
1% |
4% |
|
Nervousness |
1% |
7% |
|
Dizziness |
5% |
5% |
This is not a complete list of all the possible Armodafinil and Modafinil side effects. Modafinil can affect the blood pressure of the person in patients with cardiac disorders. Depending on the cause and the dose taken, the severity of the condition may vary.
In addition, if the condition persists or worsens with time, it is advisable to consult a doctor.
Drug Interactions Of Both Substances
The intake of Medications might result in certain Drug Interactions that might affect their efficacy as well as potency. You should consult your doctor as well as your health experts about Drug Interactions. Below are some of the medications that can interact with the two substances:
|
Armodafinil |
Modafinil |
|
Amphetamine |
Atogepant |
|
Chloramphenicol |
Axitinib |
|
Fentanyl |
Belzutifan |
|
Lumateperone |
Entrectinib |
|
Methadone |
Levomethadyl |
|
Butorphanol |
Finerenone |
Apart from the above-mentioned list, both medications can interact with other drugs. It is found that Armodafinil interacts with 444 drugs, whereas Modafinil interacts with 458 medicines.
Preventive Measures Of Armodafinil And Modafinil
Modafinil and Armodafinil are safe for use and are commonly recommended to all people below the age of 17 and above the age of 65.
However, under certain conditions, one should refrain from using Armodafinil and Modafinil as they can increase the chances of experiencing side effects.
|
Factors |
Armodafinil and Modafinil warnings |
|---|---|
Age |
The use of Armodafinil 150mg and Modafinil 200mg is not recommended for people above the age of 65 years and below 17 years. Such people must take the Nootropic under the supervision of a physician. |
For pregnant and lactating women |
Armodafinil and Modafinil are Category C drugs. Therefore it should not be taken during pregnancy and breastfeeding without consulting a doctor. |
History of abuse |
People with a history of chemical abuse should always take Modafinil or Armodafinil with a valid medical prescription, as such people are vulnerable to experiencing abuse and addiction. |
Health disorders |
Users with kidney, liver, and heart issues should not take Modafinil and Armodafinil doses without a prescription. |
Alcohol interaction |
The intake of Armodafinil and Modafinil with alcohol can make the person tolerant. In addition, it can develop signs of nausea, dizziness, and drowsiness. Moreover, it can also cause lower bp. |
Armodafinil Vs. Modafinil: Conclusion
It is believed that Modafinil and armodafinil are both strong Nootropics with similar medical benefits. However, comparing both drugs is a really difficult task. Both drugs have excelled in achieving their on-label and off-label benefits.
If you are looking for a longer time of Action, you can choose Armodafinil. And if you are looking for a lower-priced option, you can choose Modafinil.
Author's Note:
However, the above comparison is based on the facts as per our knowledge and research. You should consult your doctor before taking this medicine.
