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Modafinil Vs. Vyvanse - Which one is a better Option?

Modafinil Vs. Vyvanse - Which one is a better Option?

Last updated on 03 Apr, 2024

Modafinil and Vyvanse are two commonly used medications to improve focus and productivity. Both medications have their unique advantages as well as disadvantages.

Modafinil has a lower risk of addiction and dependence compared to Vyvanse.

In researching nootropics, it’s likely that most people have come across the most popular nootropics, Modafinil and Vyvanse.

These two medications effectively work to treat the symptoms of sleep disorders and Attention Deficit Hyperactivity Disorder.

This blog reviews everything that you need to know about Vyvanse and Modafinil.

Modafinil and Vyvanse: An Overview 

Modafinil is a pharmaceutical drug that belongs to the Schedule IV controlled substance and belongs to the Eugeroic group ( a group that promotes wakefulness properties).  The FDA approved the use of  Modafinil in 1998. 

It is a powerful stimulant that helps to treat sleep disorders like narcolepsy, obstructive sleep apnea, and shift work sleep disorders. 200 mg is the standard recommended dosage of Modafinil, though it might vary from person to person. The maximum dosage of Modafinil is 400mg/day. Consumption of more than that might lead to an overdose [1].

Vyvanse is the brand name used for the generic Lisdexamfetamine. It is a central nervous system stimulant that affects the chemicals in the brain and nerves that contribute to hyperactivity and impulse control. The FDA approved the use of modafinil to treat Attention Deficit Hyperactivity Disorder (ADHD). It also helps with psychological, social, and other problems. You should never use the medication to lose weight [2].

Similarities between Modafinil and Vyvanse 

There are different similarities between Modafinil  and Vyvanse (central nervous system stimulants):

1. Both Vyvanse and Modafinil are Category C drugs for the stage of pregnancy and breastfeeding. 

2. The use of both drugs is approved by the FDA. 

However, both medications are suggested to be taken only after consulting the doctor [3].

Dissimilarities between Vyvanse Vs. Modafinil

There are a few notable differences between both medications. They are as follows-

Generic and Brand Name 

Vyvanse is a brand name used for the generic Lisdexamfetamine. However, Modafinil 200 mg is generic and is available in different brand names, such as Modalert, Modvigil, and Provigil. 


The manufacturer of Modafinil is Cephalon Inc., which has now been acquired by Teva Pharmaceutical Industries Ltd. However, its brand drug, Modalert, is manufactured by Sun Pharmaceutical Industries Pvt. Ltd. 

In comparison,  the manufacturer of Vyvanse is Takeda Pharmaceutical Company Limited, U.S.A.

Drug Class 

Both the medications (Modafinil and Vyvanse) belong to the stimulant drug class, 

but Vyvanse is classified as Amphetamine (a group of medications that belongs to central nervous system stimulants). 

Structural Differences Between Modafinil And Vyvanse 

The molecular formula of Modafinil is C15H15NO2S. On the other hand, the molecular formula of Lisdexamfetamine is C15H25N3O.

Mechanism Of Action Of Lisdexamfetamine And Modafinil 

Vyvanse works by blocking the reuptake of dopamine and norepinephrine in the central nervous system. Both these neurotransmitters contribute to helping increase focus, motivation, alertness, effort, and sustaining thoughts. 

Modafinil's working mechanism includes inhibiting the reuptake of dopamine and increasing its level in the body. It also has the potency to increase histamine (HA), norepinephrine (NE), serotonin (5-HT), and orexin levels in the brain. 

Modafinil Vs. Vyvanse- Which Is More Affordable 

The price of Vyvanse, according to the website Single Care, is $15 per pill, whereas the price of Modafinil is $ 1.06 per pill at the reputable online pharmacy Healthmatter.

Potential Side Effects of Modafinil Vs. Vyvanse

It is necessary to know the individual side effects of the medicines before choosing the right one-

Modafinil Side Effects-

1. Skin Rashes 

2. Headache

3. Fever

4. Difficulty in breathing

5. Anxiety

6. Insomnia

7. Inflammation or blistering of  the skin

8. Pale or dilute urine. 

10. Nausea. 

Potential Side Effects of Vyvanse

1. Nausea

2. Constipation

3. Sweating

4. Weight loss

5. Irritability 

6. Restlessness.

7. Nervousness

8. Dizziness

9. Loss of appetite

10. Dry mouth. 

If any of the symptoms are severe in nature, you can consult your doctor or visit a nearby hospital. 

The side effects of Modafinil are well tolerated compared to Vyvanse; therefore, it is always Modafinil over Vyvanse. 

How to choose the right medication: Vyvanse Vs.Modafinil


When deciding which medication is right for you, it is important to consider your individual needs and preferences. 

Vyvanse is specifically considered to be more effective in treating ADHD, while Modafinil is generally considered to be more effective in treating sleep disorders. Additionally, Vyvanse can cause more side effects than Modafinil, so it is important to weigh the potential risks and benefits of each medication before making a decision. However, you should always consult your doctor before taking any medication. 

Modafinil Vs. Vyvanse:  Conclusion 

Modafinil and Vyvanse are two similar drugs, but they differ in certain factors.

But if we have to choose one drug between the two, then we would definitely choose Modafinil because Vyvanse has an increased risk of adverse events and may cause dependency. On the other hand, Modafinil has a lower risk of dependency and is generally well tolerated among most people.


Stimulant medications like Modafinil are most comparable to Vyvanse.

200 mg of Modafinil is the standard recommended dosage of Modafinil.

Modafinil is a well-tolerated drug and is chosen as it has a lower risk of dependency than Vyvanse.

The side effects of Modafinil are milder in nature than Vyvanse; therefore, it is always Modafinil over Vyvanse.

Modafinil takes 30 minutes to start its action after administration.


  1. Vyvanse Oral, WebMd. 

  2. Provigil vs. Vyvanse, Rxlist.

  3. Modafinil, Statpearls


Disclaimer: We do not provide any medical advice.

The contents of Healthma are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.