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The Best Modafinil Stacks - A Beginner’s Guide

The Best Modafinil Stacks - A Beginner’s Guide

Last updated on 27 Apr, 2024

Modafinil is combined with various medicines and supplements such as choline, coffee, nicotine, and others to increase the effects of the nootropic. It is generally safe and can have no or minimal side effects if done appropriately.

There is a high chance that you've heard about Modafinil. The potent nootropic is an effective medicine to enhance cognition and promote wakefulness. Consuming Modafinil individually ensures great perks for cognition, but it doubles its effectiveness when mixed with other substances. 

This blog is to learn how we can stack Modafinil with other substances to maximize the array of advantages. 

What Is Modafinil?

Modafinil is an FDA-approved medication designed to treat excessive sleepiness during the day caused due to narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It is a Schedule IV controlled substance, which means it has a lower potential for abuse and dependence [1]. 

Modafinil Stack

Modafinil stack is simply modafinil combined with other substances. Some of the notable reasons people stack Modafinil are -

  • Optimizes brain health through increased cognition. 

  • Improves processing of information.

  • Stacking Modafinil provides neuroprotective effects against harmful agents. 

  • Helps to sustain focus and attention for longer.

  • To create effective synergy between the combined medications. 

Medicines And Supplements To Take With Modafinil


Below are some of the most popular and effective stacks of Modafinil. 

L Theanine And Modafinil

L theanine is a well-known nootropic recognized by the FDA because of its numerous medical benefits. 

The use of Modafinil with L theanine is safe, with no reported side effects. Combining these two substances offers various benefits, such as heightened focus and alertness, uplifting moods, and promoting feelings of well-being by increasing the levels of neurotransmitters in the brain. 

- Administration guidelines:

Take L theanine 60 minutes or two hours prior to bed and several hours after taking Modafinil to combat the wakefulness-promoting effects of the nootropic [2].

Modafinil And Nicotine 

Modafinil and nicotine work in the same way by increasing the levels of certain neurotransmitters, such as serotonin, dopamine, and norepinephrine. This results in a high neurotransmitter rush that provides various benefits to the users. 

Some of these benefits include 

  • Appetite suppression helps people who wish to lose weight.

  • Helps smokers quit smoking.

  • Boost cognitive function and energy [3]. 

- Administration guidelines:

First, take nicotine gum or lozenges, followed by 200 mg of Modafinil, to experience high levels of energy throughout the whole day. 

Modafinil And Noopept

Noopept is a cognitive enhancer that is used to enhance brain function, learning, and memory.

Combining Modafinil with Noopept helps to achieve the following benefits:

      ● Improves concentration, memory, and creativity.

  • Promotes heightened wakefulness.

  • Enhances motivation and productivity in the user.

  • Indicates a state of mental clarity. 

- Administration guidelines:

One can begin by taking 200 mg of Modafinil. Then, take 10 mg of Noopept.

It is best to stack it in the morning. However, depending on the work schedule, a second dose of Noopept can be administered later in the day. 

Choline And Modafinil 

Combining Choline with Modafinil has numerous benefits. This combination helps reduce headaches, maximizes the effects of Modafinil, improves verbal memory both long-term and short-term, and lowers the symptoms of anxiety. 

- Administration guidelines:

First, take about 55 to 425 mg of choline every day. Remember, you should not take over 3,500 mg in a day. Then, start by taking Modafinil and give it some time to show its effects. Then, again, take 425 mg of choline. 

Modafinil And Ashwagandha 

Mixing Modafinil and Ashwagandha enhances creativity in users. It reduces stress and anxiety significantly among individuals. 

In a study, it was shown that 300 mg of Ashwagandha with Modafinil was associated with 56% improvement in people with severe anxiety [4]. 

Modafinil and ashwagandha can even be used when you feel overwhelmed and need to relax while getting important work done.

Modafinil And Modafinil 

Many people start with a single dose of Modafinil 200 mg. However, splitting the dose into two 100 mg doses can provide better results.

In such cases, the first Modafinil dosage should be taken in the morning, and the second 100 mg should be taken after lunch. This helps the effects of the medicine to remain effective throughout the day.

Modafinil And CBD Oil

When Modafinil is taken in the afternoon, it might lead to modafinil-induced insomnia. With enough Modafinil in the body, it might become difficult to fall asleep. This is where the CBD and stacking Modafinil come in. CBD oil helps you to fall asleep faster and enter a state of deep sleep. 

- Administration guidelines:

Take Modafinil early in the morning, and then use CBD oil 1-2 hours prior to bedtime for effective results. 

Modafinil And Caffeine

This is one of the most popular Modafinil stacks for anybody seeking the highest levels of mental focus.

Some of the benefits of mixing Modafinil with caffeine include - increased productivity and wakefulness, cognitive enhancement, and increased production of norepinephrine, which is associated with arousal and wakefulness. 

- Administration guidelines: 

  • Begin by taking the standard dosage of Modafinil, which is 200 mg, by 10 am. Make sure that you have your breakfast around the same time.

  • Followed by drinking your first cup of coffee after 60 minutes to 2 hours of administering 200 mg of Modafinil. 

  • One can take up to 2 cups of coffee over the next 3 to 4 hours. 

  • It is recommended to avoid drinking coffee after 2 p.m. to avoid any disturbances in the natural sleep cycle. 

Pros And Cons Of Modafinil Stack


Some of the advantages of stacking nootropics are as follows -

  • Provides a broader range of effects.

  • The side effects of one nootropic can be minimized or improved by another compound.

  • It helps boost cognitive effects greater than a single nootropic.

Some of the disadvantages or cons of stacking Modafinil include -

  • Stacking Modafinil has a higher risk of causing dependency because they are much stronger than individual administration. 

  • Without proper knowledge, experimenting with nootropics may lead to several health risks. 

  • Combining Modafinil with other drugs can be expensive. Even though most nootropics are affordable, using a combination of different substances will increase the cost. 

Our Final Thoughts

In conclusion, combining Modafinil with other substances offers a powerful means to enhance cognitive function. Their use demands informed decisions, responsibility, and a commitment to overall well-being. By embracing these principles, you can safely explore the potential of Modafinil stacks. 


Modafinil and Vyvanse are both stimulant drugs, but they work quite differently in the brain.

Modafinil should be avoided by people below the age of 17 and above the age of 65.

Yes, Modafinil does suppress appetite as a side effect of the nootropic.

No, Modafinil doesn’t increase Gamma-aminobutyric acid. Instead, it decreases the levels of GABA.

Avoid grapefruit or grapefruit juice while taking Modafinil.


  1. Modafinil, wikipedia

  2. Beginners Guide to Mixing L Theanine And Modafinil,

  3. R-Modafinil Attenuates Nicotine-Taking and Nicotine-Seeking Behavior in Alcohol-Preferring Rats, nature

  4. Naturopathic care for anxiety: a randomized controlled trial ISRCTN78958974, NCBI


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.