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Modafinil And Nicotine| Everything You Must Know

Modafinil And Nicotine| Everything You Must Know

Last updated on 30 Apr, 2024

Modafinil and nicotine work in the same way by increasing the levels of certain neurotransmitters. Combining these two drugs gives an insanely high level of neurotransmitter rush in the brain, which in turn leads to various benefits to the users, such as weight loss,  boost energy, and much more.

Some people are always in a constant search for substances they can combine with Modafinil to enjoy better results, Overtime different substances have been tried, such as caffeine, L-theanine, etc.

Recently, there’s been a craze about mixing Modafinil with nicotine. Is there any benefit of mixing these two substances, and is it safe? Let's find out.

- Modafinil 

Modafinil is an FDA-approved prescription drug that is used for its ability to promote wakefulness in people with certain sleep ailments such as narcolepsy, obstructive sleep apnea, and shift work sleep disorder. 

Unlike other central nervous system stimulants, Modafinil is well tolerated by most people, with fewer side effects and a lower potential for abuse. 

- Nicotine 

Nicotine is a naturally occurring chemical that is found in tobacco plants. Cigars, cigarettes, and other tobacco products contain nicotine. Nicotine is widely used for recreational purposes as a stimulant and anxiolytic (medicines that reduce anxiety) [1]. 

Nicotine And Modafinil Drug Interactions

Much like the wakefulness-promoting agent, nicotine works by increasing the levels of brain chemicals such as dopamine, serotonin, and norepinephrine. 

Combining Modafinil and nicotine together gives an insanely high neurotransmitter or brain chemical rush that provides various benefits to its users that we will discuss in the later part of this blog [2]. 

Benefits Of  Combining Nicotine With Modafinil 


Some of the significant benefits of getting Modafinil tablets are as follows - 

Suppresses Hunger

If you're someone trying to lose weight, Modafinil and nicotine might be a viable option worth exploring. 

Modafinil has been shown to naturally reduce food intake, and nicotine is known to be a common appetite suppressant. When you combine both substances, their appetite-suppressing effects could make your weight loss journey easier. 

Helps smokers quit smoking

In an animal study involving rats preferring alcohol, it was found that Modafinil not only reduced their nicotine-taking behavior but inhibited the rate at which these rats would take nicotine via intravenous injection. While this science is not definitive in humans, it appears that Modafinil cancels out the addictive properties of nicotine taken in isolation [3]. 

Boosts energy

In a study, every subject received either 400mg of Modafinil, 200mg of Modafinil, or a placebo. After two hours, they took a 2mg nicotine lozenge.

The combination of 2mg nicotine lozenge and 200 mg Modafinil boosted the perceived energy levels of the subject significantly compared to the other options [4]. 

How To Combine Modafinil With Nicotine?

The proper way to take Nicotine and Modafinil is to first take 2 mg of nicotine gum to get a dopamine boost, followed by 200 mg of Modafinil to sustain high levels of alertness and energy throughout the day. 

For extremely powerful Modafinil stack, one can do the following:

  • 2 mg of nicotine gum

  • Modafinil 200 mg

  • 200 mg of caffeine ( double espresso)

This combination should not be used for more than 1-2 times a week, with a break of at least 48-72 hours to let your system flush out the drugs. 

Side Effects Of Combing Both The Substances

There are some potential side effects of combining the two substances. Below are a few side effects of this combination. 


Both Modafinil and nicotine cause dehydration because they have diuretic effects. Either one possesses this side effect, or both of them cause dehydration. It is crucial to drink lots of water while taking this combination because even the slightest bit of dehydration can reduce mental performance significantly.


Modafinil is extremely well tolerated and does not contain any addictive properties. However, in some studies, it has been found that it is indeed possible to develop a slight tolerance to Modafinil if you're using the drug for the long term.

For this reason, it is usually not recommended to use these drugs together every day.


One of the potential side effects of this combination is nausea. Nausea is often described as the desire to vomit. This generally happens when people are not carefully dosing both drugs at the same time.

Ways To Reduce Side Effects Associated With Modafinil And Nicotine


The ultimate way to reduce the adverse events of these drugs is by taking them correctly. As stated earlier, Modafinil provides cognitive effects for 12 to 15 hours. Consequently, it is advised to take it in the morning so it won't interfere with your normal sleep cycle.

Do not split, cut, or crush the nootropic, as it can alter the dose you’re supposed to take. Never take the medicine more than the recommended dose because taking it more than the prescribed dose can lead to a Modafinil overdose.

In the case of nicotine, it is crucial to understand that smoking it in tobacco isn’t the way. The safest way to take in is in the form of nicotine gum or liquid nicotine. Make sure to source it from a reputable store.

Can I Take Modafinil And Nicotine Together - The Outlook

Using both these substances should be done only in rare cases when you absolutely need to get a huge amount of work done in a short duration of time. Apart from having various benefits, this combination comes with side effects as well.

Remember to consult a doctor before taking both drugs and use them with caution.


Yes, Modafinil does interact with nicotine and provides various benefits to its users.

Modafinil shows its effects for 12-15 hours, but the duration may vary from person to person.

Modafinil peaks within 2 to 3 hours after its administration.

Yes, Modafinil can cause loss of appetite in some individuals.

In its pure form, nicotine is a nootropic.

No, Modafinil does not deplete serotonin; in fact, it increases the levels of serotonin in the brain.


  1. Nicotine, Wikipedia. 

  2. Modafinil And Nicotine| What You Must Know,

  3. R-Modafinil Attenuates Nicotine-Taking and Nicotine-Seeking Behavior in Alcohol-Preferring Rats, nature

  4. Modafinil and nicotine interactions in abstinent smokers, pubmed


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.