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A Detailed Guide of Modafinil For Chronic Fatigue Syndrome

A Detailed Guide of Modafinil For Chronic Fatigue Syndrome

Last updated on 11 May, 2024

Treatment for excessive fatigue includes medications, particularly wakefulness-promoting medication like Modafinil, which proved to be an effective solution. The medication has a positive impact and starts working within 30 minutes after administration. 

The three basic and primary Modafinil uses are-

  • Narcolepsy, 

  • Obstructive Sleep Apnea, 

  • Shift work sleep disorders.

However, users have reported a positive review about Modafinil in the treatment of Chronic Fatigue Syndrome. This blog contains all the necessary details about how Modafinil helps treat the symptoms of chronic fatigue syndrome. 

Modafinil and Chronic Fatigue: An Overview

Modafinil is a Schedule IV drug that was approved by the FDA in 1998.  The medication belongs to the Eugeroic group ( a group that promotes wakefulness properties). The stimulant helps in the treatment of excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift work disorder. 

The nootropic is sold under different brand names, like Modalert, Provigil, and Modvigil. 

Chronic fatigue syndrome is characterized by profound fatigue, pain, and sleep abnormalities that are made worse by exertion. The disease commonly occurs in women.  The persistent feeling of fatigue lasts for at least 6 months and doesn’t go away with bed rest.  The reason for the disease is unspecified. However, there might be four contributing factors-

1. Viruses

2. A weakened immune system

3. Hormonal imbalances

4. Stress

Symptoms of Chronic Fatigue Syndrome 

Seven of the symptoms that help determine that you are suffering from Chronic fatigue syndrome are given below:

  • Insomnia

  • Fatigue and weakness

  • Inability to concentrate 

  • Forgetfulness

  • Lymph nodes

  • Confusion

  • Depression [1].

Modafinil For Chronic Fatigue Syndrome

Modafinil for Chronic Fatigue Syndrome is an effective solution for treating the symptoms. There are several in-vitro studies that have shown that Modafinil can effectively reduce feelings of exhaustion and increase energy levels in people with Chronic Fatigue Syndrome. The increase in energy levels can have a profound impact on the overall well-being of an individual. 

The nootropic works in the brain by increasing the level of neurotransmitters such as histamine, orexin, serotonin, and dopamine. The modulation of the neurotransmitters decreases the level of GABA (gamma-aminobutyric acid) and promotes a state of heightened wakefulness. The wakefulness helps them to overcome the overwhelming fatigue, allowing them to regain some normalcy in their lives [2].

Modafinil is a prescription medication that is available both offline and online. If you are suffering from Chronic Fatigue Syndrome and want to get rid of the symptoms, you can purchase the nootropic. However, before purchasing the nootropic, you should be aware of fraudulent pharmacies. Healthmatter is a trusted online pharmacy where you can purchase Modafinil online at very affordable rates and discounts. 

 What Is The Dosage of Modafinil for Chronic Fatigue Syndrome?


The dosage of Modafinil for Chronic Fatigue Syndrome varies from person to person. However, the standard dosage of Modafinil is 200mg/day. The maximum dosage is 400mg/day. It is necessary to follow the prescribed dose and not exceed the dosage, as it leads to an Overdose. Modafinil overdose might have several overdose symptoms like-

  • Insomnia 

  • Agitation

  • Anxiety 

  • Dizziness 

  • Tachycardia

  • Headache

If you miss a Modafinil dosage, skip the missed dose and follow your normal schedule. You should not overlap the doses in order to prevent overdosing. 

Administration of Modafinil

You should follow the 6 basic steps below to administer Modafinil properly-

1. Swallow the tablet as a whole with a glass of water.

2.  Avoid crushing or chewing the tablet. 

3.  You should not take alcohol along with the medication; this might make you feel more dizzy. 

4.  Take the tablet with or without food as the doctor prescribes. 

5.  You must administer the drug at the same time of the day for better effectiveness. 

6. Avoid the tablet at night to avoid unwanted effects such as insomnia ( except for shift work sleep disorder). 

Customer Reviews on Modafinil for Chronic Fatigue Syndrome

The customer reviews of medication take you to the practical field of the tablet and how it helped people in treating the symptoms. 

Modafinil has an average rating of 6.5 out of 10 in treating the symptoms of Chronic Fatigue Syndrome on the website

“I was suffering from Chronic fatigue syndrome along with symptoms of depression for 20 years. Modafinil worked as a miracle for me, without a single side effect. It’s been 13 years since I have been using the medication. “

“I was suffering from excessive Chronic Fatigue Syndrome and could barely get out of bed. After taking Modafinil, my life has changed a lot into normalcy. I can go back to work, fix my bed, clean my house, and play with my grandkids again.”

“It’s been 18 years since I was diagnosed with Chronic Fatigue Syndrome. It’s been 6 years I have been taking Modafinil, and it has changed my life in every possible way. 

Precautionary Measures while using Modafinil

There are five major precautionary measures or warnings of Modafinil for Chronic Fatigue Syndrome that are to be followed. The measures are listed below:

1. Avoid using the medicine if you are prone to allergies.  Always consult your doctor before taking the medication, as it contains the active ingredient Modafinil that might cause an allergy.

2. Do not drive, use any kind of heavy machinery or do any activity that requires an immediate response while taking the medication.

3. Discuss with your doctor about your medical history if you have problems like high blood pressure, diabetes, malfunction of the liver and kidney. 

4. Do not take the tablet during the pregnancy phase or while taking contraceptives.

5.  Avoid the medication at the stage of breastfeeding; this might harm your baby. 

Modafinil For Chronic Fatigue Syndrome: Conclusion

Chronic fatigue syndrome is an off-label use of the nootropic Modafinil. The drug works within 30 minutes after administration. The medication requires 60–75 hours to be completely removed from the system. Many users have reported positive experiences after using Modafinil.


Modafinil 200 mg is the standard recommended dosage for Chronic fatigue syndrome.

Modafinil takes 30 minutes to start working after administration.

Modafinil is a novel stimulant that distinguishes it from other stimulants.

The half-life of Modafinil is 12-15 hours.

Yes, Modafinil is a well-tolerated drug with a low potential for abuse, and is ok to take the medication daily as per the doctors’s recommendation.


  1. CFS (Chronic Fatigue Syndrome), HEALTHLINE.COM

  2. Modafinil For Chronic Fatigue Syndrome: Does it Help? Care


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.