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Modafinil And Xanax - What To Expect While Mixing Them

Modafinil And Xanax - What To Expect While Mixing Them

Last updated on 27 Apr, 2024

Modafinil and Xanax are taken together only when an individual is suffering from both panic or anxiety disorder and sleep disorder. However, it is important to remember that Xanax reduces the effectiveness of Modafinil. Therefore, always consult a healthcare provider before combining these drugs. 

Taking two or more drugs at the same time may be necessary to treat two or more different diseases. A person suffering from panic or anxiety disorder and a sleep disorder may need to take medications like Modafinil and Xanax together. Many people wonder, is the combo really safe? What can one expect from combining both medicines? Let's find out in this blog. 

Modafinil - An Overview

Modafinil, marketed under the brand names Provigil, Modalert, and Modvigil, is a wakefulness-promoting agent that is indicated for use in people over the age of 17. It is used to treat daytime sleepiness associated with the following conditions - Narcolepsy, Obstructive Sleep Apnea, and Shift Work Sleep Disorder. 

People often get Modafinil for its various off-label uses. Some of the off-label indications of this drug include -

  • Attention Deficit Hyperactivity Disorder

  • Cocaine dependence

  • Unipolar and bipolar depressive episodes

  • As a cognitive enhancer.

This nootropic is generally well tolerated; some of the common side effects of Modafinil include headache, nausea, and decreased appetite [1]. 

Xanax - An Overview

Xanax is a prescription medication that is used for certain anxiety disorders, specifically generalized anxiety disorder and panic disorder. It belongs to the benzodiazepine drug class and consists of the active drug alprazolam [2]. 

Alprazolam was invented at the Upjohn Company by Jackson Hester Jr. and was approved for medical use in 1981 in the U.S.

Differences Between Modafinil And Xanax 

There are some differences, as well as similarities, between these drugs that are mentioned in the table below. 




Generic availability




12-15 hours

11 hours

Controlled Substances Act schedule 

Schedule IV controlled substance (lower potential of abuse and dependence).

Schedule IV controlled substance. 

Side Effects 

Common side effects - headache, upset stomach, nausea, diarrhea, stuffy nose, and insomnia. 

Serious side effects include hallucinations, depression, palpitations, and ringing in the ears, among others. 

Common side effects - drowsiness, insomnia, nausea, vomiting, dry mouth, stuffy nose, headache, tiredness, upset stomach. 

Serious side effects include slurred speech, seizures, depression, memory loss, impaired concentration, and anxiety. 

First approval date 

24 December, 1998

October 16, 1981


Teva Pharmaceuticals Industries Ltd.


Drug Interaction 

Modafinil interacts with 449 medications, of which 182 are minor, 205 are moderate, and 62 are major, according to the website

Xanax is known to interact with 517 medications, of which 39 are minor, 52 are major, and 426 are moderate.

Modafinil Interactions With Xanax


Coadministering Modafinil and Xanax may come in handy to people who suffer from anxiety or panic disorder alongside sleep disorders. Since Modafinil is safe and effective, it could help promote wakefulness in people with sleep disorders, while Xanax takes care of anxiety disorder or panic disorder. 

However, there is a possibility that Xanax may reduce the effectiveness of Modafinil because of its CNS depressant effects. Thus, users may not be as focused or as alert as they should be after popping a Modafinil pill.

Can You Take Xanax And Modafinil Together 

The answer to this question is yes because an interaction checker on the website indicates a minor interaction if both drugs are combined. Several individuals who have tried mixing both these medicines have reported no serious effects. However, it is worth remembering that medicines work differently in different people; the fact the combination is safe in certain people does not guarantee that it will be safe for you [3]. 

It is also important to note that apart from Xanax, Modafinil can interact with nicotine, Lexapro, Ritalin,  Wellbutrin, and clonazepam. This is not the complete list of all the possible drug interactions of Modafinil. Thus, it is advisable for one to consult a doctor before taking any other medication or supplements with this Nootropic. 


Modafinil and Xanax are two different drugs. Mixing them can have both positive and negative effects. Combining them should only be done if absolutely needed with proper consultation from your physician. 


Modafinil is a central nervous system stimulant.

No, Modafinil is not similar to Wellbutrin. Wellbutrin is an antidepressant, whereas Modafinil is a wakefulness-promoting agent.

Yes, Xanax is a sedative.

People taking Xanax should avoid grapefruit and grapefruit juice.

Xanax starts to work within an hour of intake.


  1. Modafinil, NCBI

  2. Xanax (alprazolam), medicalnewstoday

  3. Drug Interactions between modafinil and Xanax,


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.