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Modafinil weight loss : Modafinil effects on appetite

Modafinil weight loss : Modafinil effects on appetite

Last updated on 28 Sep, 2022

Do the Modafinil weight loss stories and anecdotes make you wonder about its effectiveness? If so, then this comprehensive guide is for you. Ever since the evolution of the beauty and the cosmetic world, people have been obsessed with weight loss. However, there is more to losing weight than just its phenotypic effect on the human body. According to the CDC, 42.4% of Americans in 2020 were obese [1], and the American Medical Association identified it as a chronic disease. With several co-occurring and underlying health issues associated with this condition, people must lose weight and maintain a healthy life.

The Nootropic Modafinil for weight loss is a dynamic off-label use of the smart drug and has gained massive popularity over the last few years. Currently, most people wonder where to buy Modafinil without consultation for off-label benefits such as weight loss. So, let us have a better insight into the effect of Modafinil on appetite and how it aids in weight loss.

Modafinil for weight loss | Know the basic

Modafinil is a Nootropic commonly known for its eugeroic effects. The scientific council of the Oxford and Harvard Universities has awarded Modafinil smart drug as one of the safest Nootropics on the market [12]. The off-label use of the medication, such as its potency for weight loss, has gained massive popularity among users. Note that “Modafinil is not a fat-burning medication.” However, it helps by inducing other metabolic activities, which in turn aids in weight loss.

Possible Effects of Modafinil on Weight Loss

  • Modafinil has antidepressant properties, which can be associated with significant appetite suppression and thus make the user eat less [2]. 

  • Another possible cause for loss of appetite can be its potency to enhance the production of several neurotransmitters in the body [3]. Modafinil 200mg elevates the level of histamine and orexin in the body, which are responsible for maintaining the person’s appetite. 

  • The third scientific reason for Modafinil weight loss could be its ability to increase dopamine secretion in the body, thus helping people stay motivated. It helps them stick to their diet plans and lose weight. 

  • Modafinil enhances the energy level of the user. Therefore with the highest energy, one can stay active, further helping to burn calories. 

Modafinil vs. phentermine for weight loss

Another popular medication known to assist weight loss along with Modafinil is Phentermine. In a study published on the website Livestrong, Phentermine can induce roughly 3 to 6 lbs weight loss in a person [4]. Moreover, it can cause rapid and unhealthy weight loss that might require medical attention. Therefore Modafinil is the more sustainable and safe choice.

Does Modafinil suppress appetite? 

In a study by Gydmer A. Perez et al., the use of Modafinil can reduce the feeling of hunger in day shift workers before the lunch break. In addition, others have reported that the single use of the Modafinil 200mg dose reduces the person’s food intake [5]. It thus suggests that the administration of Modafinil suppresses appetite. 

Modafinil weight loss dosage


Modafinil weight loss dosage

 The popular Modafinil dose for weight loss is Modafinil 200mg. However, it is essential to note that FDA has not approved the off-label use of Modafinil for weight loss. Therefore, one should buy Modafinil after consulting a physician. 

Guidelines using Modafinil for Weight Loss

Following a proper diet and exercise is the best option to lose weight. Modafinil is not a weight loss medication but has shown significant weight loss in consumers. There is still no solid evidence to support these claims and mechanisms of action. You can use Modafinil as a weight-loss-supportive drug, but one cannot rely solely on this drug for significant weight loss. The intake of Modafinil is similar to most oral medications available on the market. The key features that one should take into consideration during the administration of the drug are-

  • Modafinil 200mg is available as oral tablets and thus should be taken by mouth.

  • Crushing and breaking the pill is not advisable.

  • The intake of meals before and after the consumption of the Nootropic is advisable. 

  • One should take one Modafinil pill daily. Overdosing on the medication can cause severe side effects. 

  • Doctors do not recommend the consumption of alcoholic beverages with Nootropic.

  • There is no long-term prescription use of Modafinil 200mg. After three weeks of use, one should discontinue taking the Nootropic. And after maintaining a gap period, you can restart the medication after consulting a physician.

Modafinil promoting Diet Discipline

Modafinil helps to lose fat by enforcing a strict diet routine. As the Nootropic increases the dopamine level, this, in turn, helps with avoiding the urge to snack on unhealthy junk food. One can expand the Modafinil appetite suppressant effects by integrating these: 

  • As the use of the Nootropic affects the appetite, thus to maintain a healthy living, it is advisable to have a meal before the intake of the smart drug. 

  • Modafinil is a diuretic drug; therefore, it can cause dehydration in the user. Thus, while using the Nootropic, the person should have more water. 

Modafinil brand versions for losing weight

Modafinil brand versions for losing weight

Like the generic Modafinil, its popular brand versions Provigil and Modvigil also claim to possess similar weight reduction potency. The person’s metabolism can increase by taking both these Nootropics, thus helping to lose weight [6]. 

Scientific analysis: Research-backed theories for Modafinil weight loss

Several studies indicate Modafinil's potency in assisting people's weight loss journey. A study by Gardner A. Perez et al. shows that using Modafinil 200mg and 400mg affects the calorie intake of the day shift and night shift workers [5].

Modafinil weight loss studies

 Figure 1: A study on the decrease in the food intake in association with Modafinil 200mg 

The above graph shows the intake of calories by workers before and after taking the Modafinil dose. This graph shows that using Modafinil 200mg and 400mg significantly lowers the person’s food intake. 

A second study by Angela P Makris et al. states that using Modafinil for treating obesity is a potential and well-suited option. However, further studies with repeated dosing in the overweight population are necessary. This weight loss report also calls attention to Modafinil use having fewer side effects for weight loss than other anorectic agents [7]. 

Modafinil reviews: Weight loss testimonials by users 

The Modafinil reviews from different websites support its high efficacy. The user review of the Nootropic at WebMd has a rating out of 5. Most users suggest it is easy to use and has satisfactory results.


Modafinil weight loss testimonials by users


Figure 2: Modafinil reviews (WebMd) 

Modafinil weight loss stories

A review on the Nootropic on Drugs website in march 2017 suggests that the person taking Modafinil for ADHD experienced weight loss. Also, there was no sign of long-term side effects in the user. 

A study by David C Henderson et al. proposes that using Modafinil Nootropic resulted in 10lb weight loss in the patient [8]. A Modafinil weight loss story by a Reddit user [9] states to lose 16lbs in one and half months of taking Modafinil doses. In addition, several quora users [10] also claim to experience that Modafinil suppresses appetite.

Side effects of Modafinil for weight loss 

Modafinil side effects

Modafinil can cause mild side effects from improper dosing of the Nootropic. However, there are no reports of specific Modafinil weight loss side effects. According to the FDA, several users experienced weight loss as a side effect of the Nootropic [11].

Figure 3: Modafinil side effects: Weight loss 

The above(figure 3) is not the complete list of all the side effects of the Nootropic drug. If you experience any of these effects, it is advisable to discontinue the medication immediately. In case the symptoms persist, the user should consult a doctor for proper medical attention. 

Is Modafinil weight loss a good idea? – Our Final Verdict 

We can summarise this comprehensive study on Modafinil weight loss by stating that the Nootropic does not directly induce a fat reduction in the person. The weight loss experienced by patients is due to its impact on their metabolism and appetite. The use of Modafinil for losing weight can result in an amalgamation of physical exercise, uninterrupted sleep, and a controlled diet. However, just the intake of the Nootropic for shredding extra kilos is not advisable. Since using nootropics to lose weight is not a prescription benefit, one should administer Modafinil for weight loss only under the guidance of a physician.


There are no scientific reports on using the Modafinil dose to gain weight. It helps lose weight in consumers.

Yes, Modafinil curbs appetite. It helps lower the calorie intake and thus aids in reducing weight.

No, the primary efficacy of the Nootropic does not intend for weight loss. As such, the possibility of every consumer experiencing the effect is uncommon.


  1. Adult Obesity Facts, CDC
  2. Weight loss or gain, Modafinilfacts 
  3. Modafinil weight loss, 
  4. The Average Monthly Weight Loss Using Phentermine, Livestrong
  5. Modafinil decreases food intake in humans subjected to simulated shift work, Gydmer A. Perez et al,
  6. Modafinil weight loss,
  7. Comparison of effects of modafinil and amphetamine on food intake and cardiovascular activity, Angela P Makris et al,
  8. Modafinil-associated weight reduction in a clozapine-treated schizoaffective disorder patient, David C Henderson et al, Pubmed. 
  9. Reddit user, username- birdyyumyum
  10. Does Modafinil help with weight loss? quora
  11. FDA,
  12. Adventures in brain-hacking: how an electrical stimulator boosted my IQ, The Guardian 


Disclaimer: We do not provide any medical advice.

The contents of Healthma are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.