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Armodafinil for Depression- A Detailed Guide

Armodafinil for Depression- A Detailed Guide

Last updated on 11 May, 2024

Armodafinil is a medication that helps treat the symptoms of depression. It is an off-label use of the medication, but many in-vitro studies suggest that Armodafinil is a well-tolerated drug in alleviating the symptoms of depression. 

Armodafinil is a powerful stimulant that is popular among people because of its effectiveness. 

In numerous studies, it has been found that Armodafinil is effective in treating the symptoms of depression. Hence, presenting you the  blog containing all the necessary details about Armodafinil for Depression-

  • How does it help in treating the symptoms?

  • How long do the effects last?

  • Armodafinil Dosage 

  • Precautionary Measures While Using Armodafinil for Depression 

  • Side Effects associated with it. 

Armodafinil and Depression: an Overview

Armodafinil is a prescription medication that was approved by the FDA in 2007. It is the R-enantiomer of Modafinil and belongs to the Eugeroic group ( a group promoting wakefulness properties). 

The prescription use of Armodafinil is to treat narcolepsy, obstructive sleep apnea, and shift work sleep disorder. It belongs to Schedule IV-controlled substances. 

The nootropic is sold under different brands, like Waklert, Artvigil, and Nuvigil. 

Depression is a disorder that causes fluctuation in mood and causes persistent feelings of sadness and loss of interest. This changes the way you think and act. However, it is treatable, and you can completely snap out of it. 

-Symptoms of Depression

  • Thoughts of death or suicide

  • Loss of energy or increased fatigue

  • Changes in appetite

  • Trouble in sleeping or sleeping too much. 

  • Difficulty in concentrating and making decisions. 

The above symptoms must last for about two weeks, and there must be a change in your previous level of functioning.  Medical conditions like brain tumors, thyroid, or vitamin deficiency can lead to the symptoms of depression.

You can take medications or any kind of psychotherapy to cure the symptoms of depression [1]. 

Armodafinil For Depression

Depression is a matter of concern, as 280 million people suffer from depression, according to WHO (World Health Organization) worldwide. 

There are certain studies that evaluate the use of Armodafinil in depression.  

A study made by Terrence A. Ketter, published in the year 2016, stated that Armodafinil was safe and well-tolerated in treating the symptoms of depression over 6 months of open-label treatment [2]. 

Another study made by Joseph R. Calabrese and others, published in 2014, stated that Adjunctive Armodafinil 150 mg improved the symptoms of depression and was generally well-tolerated. 

The above-mentioned studies made it clear that Armodafinil, as a nootropic, has great significance in treating the symptoms of depression and is considered a safe and well-tolerated drug. 

If you are suffering from the symptoms of depression, there’s nothing to worry about. Armodafinil is available both offline and online. You can get Armodafinil from Healthmatter, an assured online pharmacy, at very reasonable rates and discounts. 

How does Armodafinil help in Depression?


Armodafinil helps fight the symptoms of  depression by working on certain natural substances that work in our brains. It helps increase the level of neurotransmitters like thyroxin, orexin, serotonin, dopamine, and histamine and decreases the level of GABA. 

The serotonin hormone helps improve and enhance your mood.  As already mentioned above, Armodafinil helps in increasing the level of the hormone, resulting in lower signs of depression. It starts working within 30 minutes after consumption. 

How long do the effects of Armodafinil for Depression last?

The effects of Armodafinil for depression last for about 12-15 hours (half-life—the time required by medication to reduce by it’s half). A medicine requires 4-5 half-lives to be completely removed from the system. Therefore, Armodafinil requires an overall duration of 60–75 hours to be completely eliminated from the system. 

Armodafinil Dosage for Depression

The dosage of Armodafinil varies from person to person depending upon certain factors, like age and health conditions (kidney or liver dysfunction). However, The standard recommended dosage of Armodafinil for depression is 150mg/day for adults above 17 years of age. The dosage should be taken early in the morning in order to avoid insomnia.

Armodafinil missed dose 

In any circumstance, if you miss a dose of Armodafinil, you can skip the missed dose and follow your normal dosage schedule. 

Overdose of Armodafinil 

Do not overlap the doses; it might lead to an overdose. Overdose might have several symptoms, like: 

  • Anxiety,

  • Headache

  • Restlessness

  • Dizziness or fainting,

  • Hyperventilation

How to take it?

Follow five simple steps to take the Armodafinil dosage correctly:

1. Take the tablet as a whole with a glass of water.

2. Avoid chewing or crushing the tablet.

3. Avoid Alcohol while taking the medication; it might make you feel more dizzy. 

4. Take the tablet at the same time everyday for better effectiveness 

5. You can take the tablet with or without food, as the doctor prescribes [4]. 

Warnings Before Using Armodafinil For Depression:

Five simple measures or warnings that are to be followed while taking the medication are:

1. You should not take the medication if you’re allergic. It contains the active ingredient Armodafinil, which might cause an allergy. 

2. Discuss with your doctor your medical history if you have problems like diabetes, high blood pressure, kidney or liver dysfunction, heart problems, etc., before taking the medication. 

3. You should not do activities that require immediate response, such as driving or operating any kind of heavy machinery, while taking the medication. 

4. Avoid the medication during pregnancy or while taking contraceptives. 

5. Do not take the medication at the stage of breastfeeding; this might harm your baby. 

NOTE: Always consult with your doctor before taking the medication. 

Health Risk Factors Using Armodafinil

Ten notable side effects of Armodafinil are mentioned below:

  1. Indigestion

  2. Sweating 

  3. Loss of Appetite

  4. Cough

  5. Thirst

  6. Weight loss

  7. Vomiting

  8. Runny Nose

  9. Skin Rashes 

  10. Fever. 

 The side effects of Armodafinil are milder in nature; however, if any of the above symptoms occur, you should consult with your doctor or visit a nearby hospital [4].

Customer Reviews on Armodafinil For Depression

The customer reviews on Armodafinil for Depression help you a lot in choosing Armodafinil for Depression. 

Armodafinil has an average rating of 8.4 out of 10 on the website

“I was in 25 years of constant treatment for depression, but Armodafinil (Nuvigil) helped me to get my life back and remove my symptoms within 1 hour”. 

“Armodafinil (Nuvigil) brought my life back from depression. I am a mother of three children, and before Nuvigil, I was not even able to open my eyes. Now, I have become a playful mother, thanks to Armodafinil (Nuvigil).” [5].

Our Final Verdict

Armodafinil is a nootropic that helps in treating the symptoms of depression by increasing the level of serotonin, as it helps in the elevation of mood. 150 mg is the standard recommended dosage of Armodafinil that starts its action within 30 minutes after consumption for depression. 


Armodafinil has been reported to treat treatment-resistant bipolar depression.

Armodafinil is considered one of the best stimulants for depression.

Yes, Armodafinil helps in increasing hormones like dopamine, serotonin, thyroxin, orexin, histamine, etc.

Armodafinil 150mg is the standard recommended dosage for depression.

Armodafinil takes 30 minutes to kick in after its consumption.


  1. What is Depression, American Psychiatry Association. 

  2. Long-term safety and efficacy of armodafinil in bipolar depression: A 6-month open-label extension study, NCBI

  3. Armodafinil Oral Route, Mayo Clinic

  4. Armodafinil Side Effects, Mayo Clinic 

  5. Armodafinil Customer Reviews, 


Disclaimer: We do not provide any medical advice.

The contents of HealthMatter are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.