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Armodafinil Vs. Adderall- Everything To Know About These Brain Stimulants

Last updated on 15 Nov, 2023

Armodafinil vs. Adderall is an evaluation of its uses, benefits, and safety profile. Armodafinil is a safer option than Adderall, with fewer side effects and a lower risk of dependency. It is also a more affordable choice of stimulant than Adderall. 

Wondering which among “Armodafinil vs. Adderall” is a better option? We have you covered. 

Armodafinil and Adderall are two significant nootropics known for their prescription and off-label benefits. Both stimulants are noted to offer similar benefits, thus making it hard for people to decide.

This comprehensive guide will outline every crucial product detail to help you find the right Nootropic. 

Armodafinil Vs. Adderall- An overview

Armodafinil is an effective Nootropic that can help us enhance wakefulness. Moreover, it is a prescribed medicine for Excessive Sleep Disorders like Sleep Apnea, Shift Work Sleep Disorder, and Narcolepsy [1]. 

Adderall is a stimulant designed to treat the sleep disorder such as Narcolepsy and Attention deficit hyperactivity disorder (ADHD). It contains amphetamines which differ from most Nootropics. In addition, people now use this stimulant to stay focused.

 

Armodafinil

Adderall

Dosage

  • One should take Armodafinil 150 mg to 250 mg in the morning as a single dose for treating Narcolepsy.

  • In addition, Shift work sleep disorder patients should take Armodafinil 150 mg dosage 1 hour before starting the work shift.

  • Moreover, do not use Nootropics more than once a day.

The dosages of Adderall are two or three times a day. Therefore, start taking your dosage just after waking up in the morning. Similarly, continue taking it during the day by taking a gap of 4 to 6 hours. Moreover, take it orally without breaking it. 

Half-life

Approximately 15 hours

Around 9 to 14 hours

Drug class

CNS stimulant

CNS stimulant

Available dosage forms

  • Oral Pill

  • Oral capsules extended-release

  • In addition, they are also available as tablets. 

CSA schedule

Armodafinil is a medicine that has a low potential for abuse. Moreover, in the United States, it is accepted for medical use. It falls under the Schedule IV drug list. It has a lower or negligible risk of physical or psychological dependence.

Adderall is a schedule II medicine that has a high potential for abuse. However, it is currently accepted for medical use in the United States but with several restrictions. Therefore, if you abuse it, it may lead you to suffer from physical and psychological dependence.  

A Comparison Of Armodafinil And Adderall Benefits

Armodafinil-vs-Adderall

While the Armodafinil vs. Adderall comparison can be difficult as they portray similar benefits, they have prevalent advantages. Some of the comparable benefits of Armodafinil and Adderall are listed below.

Armodafinil Benefits-

- Enhanced focus and Cognition

Armodafinil can help people stay focused for hours with improved creativity, concentration, and memory. It is also associated with improving the thinking and decision-making ability of users.

- Not an amphetamine-based Nootropic

Unlike Adderall, Armodafinil doesn't contain amphetamine that helps prevent certain side effects of the stimulant, such as anxiety and excessive sweating.

- Longer half-life

The elimination half-life of Armodafinil (15 hours) is longer compared to Modafinil (12 hours) and Adderall (12 hours). It makes Armodafinil effective compared to Adderall.

- Fewer side effects

In comparison to Adderall, the side effects of Armodafinil are less frequent and severe. Many users report not experiencing any adverse effects from Armodafinil.

- Lower possibility of sleep disturbance

Adderall can be hard to sleep on; however, if Armodafinil is taken correctly, it does not affect a person's sleep cycle. 

Adderall Benefits

- Intensity

Adderall is one of the most intense stimulants available. It is too strong to fail and can guarantee to get almost all jobs done. 

- Cause High

Adderall is formulated with amphetamines that can make you feel high. It will also induce a strong sense of happiness, focus, and productivity.

- High energy level

Being an amphetamine-based stimulant, Adderall is a more potent energy booster compared to Armodafinil. 

Artvigil Vs. Adderall - Off-Label And Prescription Use

The FDA primarily approves Armodafinil for treating excessive daytime sleepiness associated with obstructive sleep apnea, Narcolepsy, and shift work sleep disorder. Likewise, Adderall is approved by the FDA for treating Narcolepsy [2].

Condition

Armodafinil 

Adderall

ADHD

Off-label 

Yes

Narcolepsy

Yes

Yes

Cognition 

Off-label 

Off-label 

Armodafinil and Adderall for Shift work sleep disorder 

Yes 

Off-label 

Obstructive sleep apnea

Yes

Off-label 

Armodafinil Vs. Adderall- The Notable Differences

- Active ingredient

Armodafinil is the generic version. It contains 150mg of Armodafinil compound in its formulation. In comparison, Adderall has a combination of dextroamphetamine and amphetamine salts.  

- Formulations

Armodafinil and its brand versions are available as oral tablets in the strengths of 50mg, 150mg, 200mg, and 250mg. Adderall, on the other hand, is available as oral tablets and in extended-release capsules. It comes in the strengths of 5mg, 10mg, 15mg, 20mg, 25mg, and 30mg.  

- Risk of abuse

Armodafinil is a Schedule IV drug, whereas Adderall is a Schedule II medication. It indicates Armodafinil has a lower risk of abuse compared to Adderall. 

- Age restrictions

Armodafinil is restricted to people of 17 years and above. However, Adderall can be taken by adults and children of 3 years and more. 

Armodafinil Vs. Adderall- Comparison Of Cost And Coverage

Coverage-and-cost-comparison-of-Armodafinil-vs-Adderall

Armodafinil is often covered by most insurance policies, whereas Adderall is not since it is a brand-name drug. Adderall can cost $315 for 30 and 20 mg tablets. However, the cost of Armodafinil is $1.60 per pill at Healthmatter [2]. 

 

Armodafinil 

Adderall

Covered by Insurance 

Yes

Often No

Covered by Medicare Part D

Yes 

No (only the generic)

Quantity 

100 to 400 pills

30 pills of 20 mg tablets

Pharmacodynamic Interactions Of Adderall Vs. Armodafinil

Armodafinil and Adderall can interact with many of the same drugs. Armodafinil is identified to interact with 432 medications, whereas Adderall is known to interact with 181 drugs. 

Armodafinil is known to cause 16 major, 230 moderate, and 186 minor interactions. On the other hand, Adderall can cause 36 major, 135 moderate, and nine minor interactions [3] [4]. 

Even though Armodafinil is prone to drug interactions, Adderall has a higher risk of causing a severe effect on the user. 

Drug Class

Armodafinil 

Adderall 

Monoamine oxidase inhibitors (MAOIs)

Yes

Yes

Hormonal contraceptives

Yes

No

Antihypertensives

No

Yes

Proton pump inhibitors (PPIs)

Yes

Yes

Serotonergic drugs

No

Yes

Immunosuppressants

Yes

No

Mixing Armodafinil And Adderall-  Is It A Wise Decision?

Many people take Armodafinil and Adderall simultaneously in the hope of getting higher brain activity and doubling up their functioning. But is this interaction safe?

Armodafinil can interact individually with the two active compounds of Adderall. 

Mixing-Armodafinil-and-Adderall

Mixing Adderall and Armodafinil can trigger overstimulation that can result in adverse effects. Such people are more likely to experience nausea, anxiety, twitchiness, palpitation, and irritability [5]. 

Side Effects Of Adderall And Armodafinil

Adderall cause significantly more side effects than Armodafinil, which is a well-tolerated drug. Thus, Armodafinil has a lower poteny for causing side effects. 

The severity of the adverse effects of Adderall is also higher compared to Armodafinil [6] [7].

Armodafinil 

Adderall

Headache

Fever

Nausea

Nausea

Weight loss

Muscle spasm

Diarrhea

Addiction

Insomnia

When mixed with alcohol, it can cause a heart attack.

Hypertension

Diarrhea

 

High blood pressure.

 

Muscle twitching.

Note - This is not the complete list of all the possible side effects of Adderall and Armodafinil. Before taking these nootropics, consult your doctor and talk about the possible side effects of them.

Nuvigil vs. Adderall- Warning And Precaution

The use of Armodafinil and Adderall is contradicted in people with kidney, liver, and heart issues. Administering these stimulants can increase the risk of cardiac disorder and elevate heart rate, blood pressure, and stroke.

Adderall and Armodafinil use can also increase the risk of psychiatric events such as depression, hallucinations, aggression, mania, and delusional thinking. The possibility of these is higher in people with a history of mental health disorders. 

In rare cases, these stimulants can cause allergic reactions and severe rashes like Stevens-Johnson syndrome. 

Apart from these, the use of Adderall can cause other health risks such as visual disturbances, growth suppression (in children), and serotonin syndrome. 

Armodafinil vs Adderall- Our Final Verdict

Armodafinil and Adderall are both nootropics that can help us stay active. However, if you ask us which of these two is better, it would undeniably be Armodafinil. 

Armodafinil is a safer option than Adderall as it is a Schedule IV drug with lower dependency. It is also associated with minor and less frequent side effects than Adderall. 

The price of Armodafinil is lower compared to Adderall and is often covered by insurance, whereas Adderall is not.


FAQ's

Though Adderall can offer “feeling high” effects and enhance our mood, Adderall is not an approved treatment for depression.

Armodafinil can work as a very effective mood enhancer. It can be an effective solution for treating depression as it offers mood-brightening effects.

Armodafinil can help in treating ADHD. As such, people constantly fidget and struggle with staying attentive; using Armodafinil can help them stay focused and increase their attention span.

Armodafinil is a cognitive enhancer that can boost our focus and motivation.

Armodafinil can produce psychoactive and euphoric effects.

Adderall can be habit-forming if you use it for a longer period. It is a schedule II drug that has the risk of abuse.

Adderall should not be taken without ADHD as it may produce excessive dopamine, causing euphoria, enhanced energy levels, and possible physical and emotional side effects.

Adderall can offer a little, but a mixed cognitive enhancement. Therefore, it is relevant to neurocognitive enhancement in people.

The half-life of Armodafinil is longer compared to Adderall. Therefore, the effect of Nuvigil is longer and more effective.

Yes, Armodafinil is a central nervous system stimulant.

Taking Armodafinil with Adderall is not recommended.


References-

  1. Armodafinil, Wikipedia
  2. Nuvigil vs. Adderall: Differences, similarities, and which is better for you,singlecare

  3. Adderall Interactions, drugs.com
  4. Armodafinil interaction, drugs.com. 

  5. Modafinil vs Adderall| Can Modafinil and Adderall Be Taken Together, therecoveryvillage
  6.  Adderall, drugs.com

  7.  Armodafinil, mskcc

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Disclaimer: We do not provide any medical advice.

The contents of Healthma are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.