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Modafinil Interactions - A Detailed Guide

Last updated on 25 Jan, 2024

Modafinil can interact with certain medications, alcohol, health conditions, and food. One should always be cautious while mixing Modafinil with other substances to avoid negative consequences. 


Modafinil (sold under brand names like Modalert, Modvigil, and Provigil) is a prescription FDA-approved tablet that is used to treat daytime sleepiness caused by sleep disorders like obstructive sleep apnea, shift work sleep disorder, and narcolepsy. This medication can interact with alcohol, nicotine, and other medications.

An interaction can take place if one substance causes another substance to have a different effect than expected.

Keep reading this blog to learn about Modafinil's possible interactions and a few warnings that one should be aware of while taking this popular drug. 

Modafinil Drug Interactions

Before you order Modafinil, discuss with your doctor any medication you take. Sharing this information with them will help prevent possible drug interactions. 

Modafinil and Tramadol

Tramadol is a powerful pain medication used for moderate to severe pain. Modafinil, when interacted with tramadol, decreases the blood levels of tramadol, which can make tramadol less effective. Additionally, stopping the use of modafinil can increase the risk of experiencing side effects from tramadol, which include respiratory depression, seizures, and serotonin syndrome [1]. 

Modafinil and Viagra

Viagra is a medication that is used to treat impotence (inability to sustain and get an erection) in men. When Modafinil interacts with Viagra, the therapeutic efficacy of Viagra decreases. 

Modafinil and Xanax

Xanax is a prescription-based medication that is used to treat anxiety and panic disorder. Taking Modafinil and Xanax together may decrease the plasma concentration of xanax. 

Modafinil and Propranolol

Propranolol is a beta-blocker that is indicated to treat high blood pressure, irregular heart rate, performance anxiety, essential tremors, and thyrotoxicosis capillary hemangiomas.

Modafinil may elevate the effects and blood levels of propranolol when interacted.

Modafinil And Adderall Together

Adderall is a prescription drug indicated for the treatment of attention deficit hyperactivity disorder. 

When Modafinil is combined with Adderall, it can worsen the side effects of one or both drugs and can cause overstimulation. 

People taking these drugs together are more likely to feel nauseous, anxious, and get a headache. Therefore, mixing these drugs is not a good idea [2].  

Modafinil And Antidepressants

Antidepressants are a type of medication that is used to treat depression and anxiety. 

Modafinil and Antidepressants, when combined together, reduce the severity of depression more effectively. In a study, it was concluded that Modafinil appears to be an augmenter of antidepressants, especially in people with residual fatigue or tiredness [3]. 

Modafinil Interactions With Other Drugs 


Modafinil And Birth Control Pills 

Birth control pills are drugs that are used to prevent pregnancy. Modafinil, when interacted with birth control pills, reduces the effectiveness of these pills, thereby increasing the chances of getting pregnant. 

Modafinil And Nicotine

Nicotine is a chemical that occurs naturally and is found in tobacco plants. Modafinil and nicotine work in a similar manner by elevating the levels of certain brain chemicals. Combining Modafinil and nicotine gives a high level of neurotransmitter or brain chemical rush, which in turn leads to various benefits to its users, such as weight loss and higher energy levels, and helps smokers quit smoking.  

Modafinil And Alcohol Interaction

People should refrain from combining Provigil and alcohol. Modafinil promotes wakefulness, but alcohol can make you feel sleepy. Therefore, alcohol may reduce the effect of Modafinil. 

Combining Modafinil with alcohol can cause complications ranging from increased alcohol tolerance to blackouts. 

Modafinil Health Interactions 

Modafinil And Blood Pressure

Central nervous system stimulants such as Modafinil have been shown to increase blood pressure. Caution should be exercised for patients with preexisting hypertension. All patients taking Modafinil should be closely monitored for changes in blood pressure.

Kidney Problems

Your kidney is responsible for clearing Modafinil from the body. If you have kidney issues, the drugs could build up in the body, increasing the risk of side effects from Modafinil. If you have severe kidney problems, you will be prescribed a lower dose of the drug. 


Modafinil during pregnancy is suspected to cause congenital malformation. Therefore, Modafinil should not be used by pregnant women. 

Certain Heart Conditions 

Modafinil can cause chest pain, palpitations, and shortness of breath in people with mitral valve prolapse or enlarged left ventricle. If you've any heart condition, talk to your healthcare provider to see if Modafinil is right for you. 

Modafinil Interaction With Certain Foods 


Modafinil And Coffee

Coffee is a popular drink that is made by brewing grounded and roasted coffee beans.   

When caffeine interacts with Modafinil, it can beat fatigue in sleep-deprived individuals, enhance complex making, and reduce the sensitivity to pain caused by loss of sleep.

Modafinil And Grapefruit

Do not take grapefruit or grapefruit juice while taking Modafinil because it may increase the side effects of the nootropic [4]. 

Modafinil Warnings - Things To Remember 

Some of the warnings that one should be aware of are as follows - 

  • Do not take Modafinil if you’re allergic to any of the ingredients present in the drug.

  • Do not mix Modafinil with supplements and herbs if not recommended by your physician.

  • Take the medicine at the same time every day, and avoid taking it before bed because it can lead to insomnia. 

  • Read the label of the medicine properly and follow all the instructions.

  • Modafinil can cause drowsiness, so avoid operating heavy machinery.

Our Final Thoughts 

Modafinil is a powerful medicine that is well known because of its effects. Although we have provided some interactions that might happen if this drug is combined with other substances. However, this blog does not provide all the things that Modafinil might interact with. Therefore, as we have mentioned already, talk to your doctor or pharmacist first before combining Modafinil with other substances.


People below the age of 17 and above the age of 65 should not take Modafinil.

People should avoid grapefruit or grapefruit juice while taking Modafinil.

There are various medicines that interact with Modafinil. Some of these include HIV drugs, certain antifungals, monoamine oxidase inhibitors, cyclosporine, and warfarin, among others.

Yes, Modafinil does suppress appetite in some people as a side effect.

Modafinil takes around 30 minutes to kick in after consumption.


  1. Drug Interactions between Provigil and tramadol,

  2. Mixing Modafinil With Adderall, recreatelifecounseling

  3. Modafinil augmentation of antidepressant treatment in depression, europepmc

  4. MODAFINIL (Generic for PROVIGIL) Lifestyle Interactions, wellrx.


Disclaimer: We do not provide any medical advice.

The contents of Healthma are for informational purpose only and is taken by a thorough evaluation of research papers and Journals. We do not provide professional medical advice, treatment, or diagnosis. We advise all readers to consult a physician before consuming any medication mentioned on the website.